Semaglutide: A New Weight Loss Solution

Nov 1, 2024

Semaglutide (Ozempic) for Weight Loss: Key Points

Introduction

  • Semaglutide, also known as Ozempic, is a medication initially used for treating diabetes, now approved for chronic weight management since 2021 by the U.S. FDA.
  • It's a significant development in weight loss treatment, especially for the 70% of American adults who are obese or overweight.

What is Semaglutide?

  • Semaglutide is part of the glucagon-like peptide-1 receptor agonists (GLP-1 RAs) class.
  • It mimics the GLP-1 hormone to help produce insulin and reduce blood sugar.
  • Higher doses suppress appetite and signal fullness, aiding in significant weight loss when combined with diet and exercise.

Usage for Weight Loss

  • Marketed under the brand name Wegovy for weight loss.
  • Typical weight loss dose: 2.4 mg weekly via subcutaneous injection.
  • Other brands like Ozempic and Rybelsus are used off-label due to high demand.

Effectiveness in Non-Diabetics

  • Studies show semaglutide results in significant weight loss compared to lifestyle changes alone.
  • Initial studies: 15% body weight loss in semaglutide users over 68 weeks, versus 2.4% in non-users.
  • Weight tends to regain if medication is stopped.

Side Effects

  • Generally mild, including:
    • Dizziness
    • Fatigue
    • Gastrointestinal issues (such as diarrhea, constipation)
    • Headaches
    • Stomach issues (nausea, vomiting)
  • Start with a lower dose to minimize side effects.

Suitability

  • Recommended for individuals with:
    • BMI of 27kg/m2 or greater with weight-related conditions.
    • BMI of 30kg/m2 or greater.
  • Not recommended for individuals with:
    • History of thyroid cancer
    • History of gallbladder disease
    • History of pancreatitis
    • Multiple endocrine neoplasia syndrome type 2 (MEN2)

Conclusion

  • Consult a primary care physician before starting semaglutide for weight loss.
  • Essential to consider personal and family medical history.

Related Resources

  • Learn more about weight loss medications with your primary care physician.

This summary is based on the article from UCLA Health regarding the use of semaglutide for weight loss. For further details, visit UCLA Health.