Engineering an Epigenome Editor | Raising Health

Podcast Overview

• Podcast Title: Raising Health
• Episode Title: Engineering an Epigenome Editor
• Date: July 22nd, 2021
• Duration: 31:38
• Episode Number: 61
• Host: Lauren Richardson
• Guest: Jonathan Weissman, Professor of Biology at the Whitehead Institute at MIT
• Contributor: Vijay Pande
• Platform: Simplecast

Episode Highlights

• Main Topic: Discussion on a study about creating tools for genome modulation using CRISPR-based epigenome editing.
• Key Technique: Explores the use of CRISPR as a backbone for developing tools that can switch genome regions on or off with high specificity.
• Advantages of Epigenome Modulation:
  • Offers precise control over genome functions without altering the DNA sequence.
  • Allows for reversible modifications.
• Applications:
  • Laboratory research.
  • Potential clinical applications in treating diseases.

Key Participants

• Jonathan Weissman: Senior author of the related study, discussing the development and implications of the new tools.
• Vijay Pande: General partner at a16z, involved in the discussion.

Study Details

• Referenced Article: "Genome-wide programmable transcriptional memory by CRISPR-based epigenome editing."
• Publication: Available through DOI link (DOI: 10.1016/j.cell.2021.03.025)

Summary

• The episode delves into the potential of epigenome editing to revolutionize how scientists can influence gene expression patterns.
• Highlights the precision and specificity of the CRISPR-based tools being developed.
• Discusses broader implications for research and medicine, particularly in controlling genetic functions without permanent changes to the DNA.