Scopolamine: A Study Guide

Overview

• Scopolamine is an anticholinergic drug primarily used to treat motion sickness.
• It is known for its ability to reduce acetylcholine signaling in the brain.

Mnemonic for Memory

• Scope: Symbolizes scopolamine ("scopolamine scope").
• Cola Bottles: Represent acetylcholine (sounds like "cola").
  • Empty cola bottles signify the reduction of acetylcholine signaling.

Clinical Uses

1. Motion Sickness Treatment

   • Effective for vestibular nausea (sea sickness, car sickness).
   • Administered as a skin patch behind the ear.
     • Takes about 4 hours to take effect.
     • Lasts for approximately 72 hours.

2. Reduction of Oral Secretions

   • Used during anesthesia or intubation to prevent aspiration.
   • Prescribed to quiet "death rattle" in end-of-life care.
   • Mnemonic Aid: Dry, cracked tongue to symbolize reduced oral secretions.

Side Effects

• Known as Anticholinergic Side Effects or Anticholinergic Syndrome.
  • Urinary Retention: Difficulty urinating.
  • Constipation: Slowed bowel movements.
  • Pupil Dilation: Enlarged pupils.
  • Dry Mouth: Reduced saliva production.
• These effects result from blocking the parasympathetic "rest and digest" system.

Recap

• Scopolamine is an anticholinergic medication used for treating motion sickness and reducing oral secretions.
• Causes typical anticholinergic side effects including urinary retention, constipation, dry mouth, and pupil dilation.

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