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What genetic mutation is commonly associated with adenomatous polyps?
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Mutation in the adenomatous polyposis coli (APC) gene.
Which type of gene is the APC gene: oncogene or tumor suppressor gene?
Tumor suppressor gene.
What is the role of the APC gene?
The APC gene is a tumor suppressor gene that helps regulate cell growth.
What is the significance of the division of cells lining the colon and rectum?
These cells are constantly dividing, which can lead to the formation of colorectal polyps.
What process is disrupted due to the mutation in the APC gene in colorectal cells?
The regulation of cell growth is disrupted, leading to rapid cell division and polyp formation.
Where does the rapid division of epithelial cells due to a mutated APC gene occur?
In the colon or rectum, leading to the formation of polyps.
What distinguishes benign colorectal polyps from malignant ones?
Benign polyps do not invade nearby tissues, whereas malignant polyps can invade nearby tissues over time.
What is a key characteristic that differentiates adenomatous polyps from other colorectal polyps?
Adenomatous polyps are associated with mutations in the APC gene.
What is the most common type of colorectal polyp?
Adenomatous Polyps (Colonic Adenomas)
What is the medical term for the most common type of colorectal polyp?
Adenomatous Polyp or Colonic Adenoma.
What is a colorectal polyp?
A small clump of epithelial cells forming a bump or overgrowth along the lining of the colon or rectum.
What part of the body are colorectal polyps found?
Colorectal polyps are found along the lining of the colon or rectum.
What happens when there is a mutation in the APC gene?
A mutated APC gene leads to rapid division of epithelial cells, resulting in the formation of polyps.
Can all colorectal polyps become cancerous?
No, only some polyps have the potential to become malignant over time.
Why do some colorectal polyps become malignant?
Some polyps can become malignant over time if they acquire additional mutations that enable them to invade nearby tissues.
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