Sulfasalazine Overview

Introduction

• Anti-inflammatory drug.
• Used to treat autoimmune inflammatory diseases.
• Symbolized by rotten egg (sulfa drugs) and fire extinguisher (anti-inflammatory action).

Clinical Uses

• Treats rheumatoid arthritis, irritable bowel syndrome, and ulcerative colitis.

Side Effects

Allergic Reactions

• Severe allergic reactions possible, especially in patients with sulfa allergies.
• Symptoms: difficulty breathing, rashes, hives, swelling.
• Monitor closely if patient has never taken sulfa drugs before.

Crystalluria

• Symbolized by yellow crystal and kidney beans.
• Crystals form in urine, risking kidney failure.
• Keep patient hydrated to minimize risk.

Photosensitivity

• Increases susceptibility to sunburns.
• Patients should wear sunscreen and avoid direct sunlight.

Orange Discoloration

• Can cause orange discoloration of skin and urine.
• Benign and normal side effect; not a reason to stop medication.

Folic Acid Deficiency

• Ruined folder symbolizes folate (folic acid) deficiency.
• Sulfasalazine can lower folic acid levels.
• Patients may need folic acid supplements, but follow doctor's instructions to avoid reducing medication effectiveness.

Recap

• Sulfasalazine treats rheumatoid arthritis, inflammatory bowel disease, and ulcerative colitis.
• Watch for allergic reactions due to sulfa component.
• Side effects include crystalluria, photosensitivity, orange discoloration, and folic acid deficiency.
• Patients may need hydration and folic acid supplementation.

Conclusion

• Anticipate and manage side effects accordingly.
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