Proton Pump Inhibitors (PPIs)

Introduction

• PPIs can be remembered by the acronym P's of PPIs.
• Recognizable by the suffix -prazole.

Examples of PPIs

• Esomeprazole (Brand name: Nexium)
• Omeprazole (Brand name: Prilosec)
• Pantoprazole (Brand name: Protonics)

Function and Uses

1. Pause Acid Production

• Inhibit/stop the proton pump in the stomach from producing excess acid.

2. Prevent Ulcers

• Prescribed to prevent/treat duodenal and gastric ulcers.
• Commonly ordered in hospitals due to stress, surgery, or certain medications.

3. Treat H. Pylori

• Helps with the stomach bacteria H. pylori.
• Decreases stomach acid in conditions like GERD.

4. Porous and Spongy Bones

• Long-term use can lead to bone fractures or osteoporosis.
• Causes decreased calcium absorption.

5. Potential Infection

• Decreased stomach acid leads to increased susceptibility to infections.
• Notable infection: C. diff (serious GI infection).
• Other side effects: nausea, diarrhea, upset stomach.

Administration Guidelines

Prior to Meals

• Take 30 minutes before the first meal of the day.
• Educate patients about taking calcium and vitamin D supplements to prevent osteoporosis and fractures.

Prevent Taking Pain Meds

• Avoid pain medications that irritate the stomach (e.g., aspirin, NSAIDs like Advil).

Summary of Key Points

• Suffix: -prazole (e.g., omeprazole).
• Function: Pause/inhibit acid production.
• Uses: Prevent ulcers, treat H. pylori.
• Side effects: Porous bones, potential GI infections.
• Guidelines: Take prior to meals, avoid pain meds that irritate the stomach.

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