Lecture Notes: Understanding Cancer and Metabolic Theory
Introduction
Cancer is highly preventable.
Thomas Seyfried, a professor of biology, genetics, and biochemistry, challenges the mainstream view of cancer as a genetic disease, suggesting it is a metabolic disorder.
The State of Cancer
Cancer diagnosis and death rates are increasing, with almost 2 million new cases per year in the U.S.
Lung cancer is the most prevalent for both men and women.
Despite anti-smoking campaigns, cancer rates continue to rise.
Metabolic Theory of Cancer
Cancer cells depend on ancient fermentation pathways for energy, unlike normal cells that use oxidative phosphorylation.
Historical and tribal evidence suggests cancer is a lifestyle-induced disease.
Metabolic Therapy
Metabolic therapy involves restricting glucose and glutamine, transitioning the body to ketone bodies.
This approach can be used for both prevention and treatment of cancer.
Historical Context and Research
Otto Warburg's research in the 1920s indicated cancer cells take in less oxygen and depend more on glucose.
Metabolic defects in cancer cells lead to inefficient energy production.
Prevention and Lifestyle
Exercise and a low-carbohydrate diet may reduce cancer risk by keeping mitochondria healthy.
Lifestyle factors such as stress, sleep, and diet can impact cancer risk.
Carcinogens and Environmental Factors
Carcinogens like microplastics and certain chemicals can cause mitochondrial damage.
Keeping a healthy lifestyle can mitigate some risks.
Treatment and Therapeutic Resistance
Metabolic therapy can be combined with lower doses of chemotherapy for effectiveness.
There is resistance in the medical community to shift from the genetic to the metabolic view.
Success Stories and Case Studies
Anecdotal evidence and case studies (e.g., dog with cancer, Pablo Kelly) show prolonged survival with metabolic therapy.
Conclusion
Paradigm shifts in cancer treatment are challenging but necessary.
Seyfried emphasizes patient self-responsibility and understanding of metabolic health.
Key Points
Cancer is prevalent but preventable with lifestyle changes.
Metabolic therapy offers a promising alternative to traditional cancer treatments.
Maintaining mitochondrial health is crucial for cancer prevention.
The scientific community is slow to acknowledge the metabolic theory despite evidence.