Exploring Thymus Rejuvenation in Medicine

Sep 6, 2024

New Frontiers in Functional Medicine Podcast

Podcast Overview

  • Established in 2015.
  • Over 200 episodes, 2 million listens.
  • Focus: Functional medicine, epigenetics, longevity.
  • Goal: Actionable content for clinicians, interesting for general audience.
  • Acknowledgment of sponsors: Biotics Research, Rupa Health, Integrative Therapeutics.
  • Access full transcripts and additional resources at drcarofitzgerald.com.

Guest: Dr. Greg Fahey

  • Renowned cryobiologist and chief science officer at Intervene Immune.
  • Pioneer in thymus regeneration and age-related immune decline treatments.
  • Led the TRIM study on thymus rejuvenation and epigenetic age reversal.

Key Discussion Points

Thymus Rejuvenation and Age Reversal

  • 2019 Publication: Evidence of biological age reversal using epigenetic clocks (Horvath clock).
  • TRIM Study: Demonstrated thymus rejuvenation, reversal of human epigenetic age.
  • TRIM-X Studies: Follow-up studies to reproduce and expand original results.
  • Key Findings:
    • Reversal found in multiple aging clocks.
    • Correlation with reduced cancer risk and mortality.
    • Physiological improvements like VO2 max increase, hair darkening.

Treatment Protocol

  • Components: Human growth hormone, DHEA, metformin, vitamin D, zinc.
  • Individualized Dosing: Adjustments based on personal biology and response.
  • Challenges:
    • Balancing hormone levels, particularly for women.
    • Managing potential side effects.

Research and Development

  • AI and Expert System: Developing systems to automate treatment adjustments.
  • Commercial Expansion: Plans to offer treatment as a medical service in the UK.

Future Directions

  • Potential for Autoimmunity and Transplant Rejection Therapy:
    • Thymus can be reprogrammed to treat these conditions.
    • Current focus on developing this approach in animal models.
  • Additional Studies and Trials: Continuing to refine and expand therapeutic protocols.

Future Topics

  • Impact of diet, nutrition, and exercise on longevity and health.

Call to Action

  • Consider leaving a like or review for the podcast.
  • Follow ongoing research and updates at drcarofitzgerald.com.

Sponsors Acknowledgment

  • Thanks to Rupa Health, Biotics, Integrative Therapeutics, Timeline, and OneSkin for their support.