why hcg is better than gonadorellan or maybe just more info about ghana dorellen um for all the guys stuck using using it because our clinics switched so what's your guys opinion i have none this is the trt and hormone optimization youtube channel and if you want to learn all about the science-based information on this topic consider subscribing hit that notification bell and you'll be on your way because i think you have more experience with it i know the mechanism i'm gonna i'm gonna take it as a two-part question uh part one is gonna be availability of hcg i wanna clarify the whole hcg is no longer a round thing it was not banned by the fda it was reclassified it used to be something where if you had like um like 50 amino acids it was classified as a protein and now they knocked it to 40 or some along those lines where now hcg is considered a biologic so it's just classified differently by the fda so now the drug manufacturers or compounders have to address the production of hcg differently than before before it was a peptide and it's no longer a peptide so in order to produce a manufacturer compound a medication that is now classified as a different group the pharmacy must be licensed to compound the medications of that group my understanding from speaking with a few pharmacy owners is that in order to compound biologics you must have a biologic license and certain equipment and certain sterility testing uh and this was nothing more than a push to sell more pregnant which is the name brand of hcg i believe jordan mark is is the producer of pregnant uh and it uses a fertility drug pr viral pregnancy is going to cost you about three times the uh the cost of hcg so because hcg became popular and prevalent as a result of trt uh supplementation alongside they felt that pregnant was being impacted and naturally the lobby said well we can't ban it but we can reclassify it and by that way we can sort of ban it so pharmacies are still making it so long as they have a biological license now if your clinic does not have an account with a pharmacy that that that has a very expensive biological license they're going to tell you hcg is no longer available it is available we deliver it daily to patients through my clinics and it is just a matter of them going to the right channels that out of the way the difference from a medical perspective between gonadorellin and and hcg so gonadolin from my research and i haven't experienced it with patients because we still use hcg is it is a step above hcg when it comes to the chain of command okay of where do we address the production of testosterone so if we think of the master gland in the hpta or the endocrine system for that matter it's the hypothalamus and then below the hypothalamus you have its assistant which is the control panel and that is going to be the pituitary or interior pituitary in the case of the hpta and then from there we go on to the testicles so when the hypothalamus releases a gonadotropin releasing hormone known as gnrh that then signals your pituitary gland to go ahead and produce luteinizing hormone and follicle stimulating hormone which then act on the testicles which is the actual factory of the process hcg is an analog analog simply means a mimicker of lh or luminizing hormone so when we're administering hcg we are telling the testicles go ahead and produce testosterone and the pituitary no longer has to function with the lh release and in turn the hypothalamus no longer has to release gnrh when we take an anaeroline we are essentially mimicking gnr rage because it's a gnrh analog which then hits the pituitary and tells the pituitary go ahead and produce lh and then in turn go down to the testicles for testosterone here's the problem when a man has secondary hypogenetism not tertiary not primary secondary the failure is at the pituitary level this means the pituitary gland does not secrete sufficient levels of lh even though it is being stimulated by the hypothalamus how do we know it's being stimulated because the low t will not shut off that loop yet the lh is insufficient so gonada allen is only going to ask the pituitary to do a job that it's already failing at doing so guys with secondary hypogonadism are not going to benefit from gonadorel in the same way as they will with hcg and guys that don't have secondary but have primary hypogonadism are not going to benefit from either one because the testicles have already failed so for me to take a step from the failing point and go backwards everything behind that line is no longer going to be acting in the way that you expect of it so i'm not going to say gonadarellan is not better than nothing i'm just going to say that to me it's not a replacement for hcg because of the mechanism of action being slightly different so if you have anything to add to that i totally agree i mean we do know sometimes you can push those pathways if you overwhelm them with that medicine right you might get a little bit extra out of it even if the pituitary is kind of we don't say failed but on the it's not running up to speed so you might get a little push but um i agree with you i don't see the the reasoning behind it the only thing i could see is if maybe if you had completely normal function your guys who are just taking testosterone that didn't have the failure right like they're just taking it then you might get the benefit of it um but yeah if you actually have secondary or primary or combo it's not a great option hey thanks for watching and now click on one of these thumbnails to learn a ton more about trt and hormone optimization