Lecture Notes: Exploring the DMT State

Introduction

• Speaker recounts a past experience in the room and mentions a book for sale.
• This lecture follows up on a morning talk about the DMT state.

Importance of Studying DMT

• Questions posed: Is the DMT world real or hallucinatory?
• DMT experience is brief, peaking at about 5 minutes.
• Typical administration via vaping is common but might limit study.

Advancing DMT Research

• Rick Strassman's Work:
  • Collaborated with Rick Strassman for continuous DMT immersion research.
  • Published a paper in 2016 on prolonged immersion using target control intravenous infusion.

Pharmacological Properties of DMT

• DMT compared to anesthesiology drugs.
• Requires maintaining stable levels in the brain.
• Essential properties for target control infusion:
  • Rapid onset
  • Short duration
  • Low tolerance
  • Favorable side effect profile

Continuous Infusion Methodology

• Utilizes target control intravenous infusion, similar to anesthetic delivery.
• Introduction of drugs into a complex system of distribution and metabolism.
• Aim to maintain stable DMT concentration in the brain over time.

Tolerance and Side Effects

• DMT has no toxic metabolites; clean removal from the body.
• Rick Strassman’s studies showed no tolerance buildup in repeated doses.

Developing a Pharmacokinetic Model

• Based on blood concentration data from Strassman’s research.
• Models the typical DMT dose and predicts brain concentration changes.
• Ideas for a continuous infusion protocol using a bolus-elimination-transfer method to maintain DMT levels.

Applications and Future Prospects

• Exploration requires interdisciplinary teams:
  • Mathematicians, anthropologists, psychologists, cartographers, linguists, etc.
• Explorative potential with prolonged immersion.
• Future vision of prolonged DMT experiences facilitated by technology.

Timothy Leary’s Influence

• Historical context on attempting to bring information back from DMT experiences.
• Leary's experiential typewriter envisioned for real-time communication from DMT space.

Practical Considerations for Extended States

• Considerations include nutrition (total parenteral nutrition) and waste management.

Speculations on Future

• Imagining technology allowing extended stays in the DMT state akin to "Matrix" style pods.
• Potential for humans to explore other realms or even leave the material world.

Closing

• References to literary and scientific inspirations.
• An invitation to further explore the "universe next door."