If cells are implanted in tissue without matrix support, they often die. Therefore, the delivery of cells within a matrix is key to many emerging therapeutic strategies. Today, the repair of defects in the contour of the skin remains a challenge for surgeons.
Fat-derived stem cells are increasingly implanted under the skin in an attempt to correct defects resulting from trauma or aging, but the results are highly variable. It is now widely recognized that cells combined with a matrix are essential for these applications in dermatology and reconstructive surgery.