factor five lighting is a disorder where blood clots form more easily due to a mutation in a clotting protein called factor five factor five lyden is the most common hypercoagulable disorder in people of caucasian descent and was named after the town leiden in holland where the disease was first described now factor v leiden is a hemostasis disorder hemostasis is the process where blood flow is stopped after there's damage to a blood vessel and it has two steps primary hemostasis involves the formation of a platelet plug at the site of injury and secondary hemostasis involves the coagulation cascade where several clotting factors come into play to form a fiber mesh over the platelet plug to reinforce it forming a blood clot sign up for a free trial today and watch the full video on osmosis.org [Music] bye