Lecture Notes: Benefits and Uses of Calis (Tadalafil) and Sealas

Overview

• Calis (Tadalafil): A phosphodiesterase type 5 inhibitor.
  • Increases nitric oxide and cyclic guanosine monophosphate levels in smooth muscles.
  • Promotes blood flow to the penis, improving erectile function.
  • Medically used for blood pressure management and erectile dysfunction.
  • Popular in fitness for enhancing blood flow and achieving a "pump."

Medical Applications

• FDA Approved Uses:
  • Erectile Dysfunction: Calis once per day (2.5-5mg) or on demand (10-20mg).
  • Benign Prostate Hyperplasia: 2.5-5mg once daily.
  • Pulmonary Arterial Hypertension: Off-label use, generally 2.5-5mg daily.
• Warnings:
  • Potential for vision or hearing loss.
  • Risk of priapism (erection lasting over 4 hours).

Drug Interactions

• Interacts with:
  • Alpha blockers, beta blockers, nitrates, other PDE5 inhibitors.
  • CYP3A4 inhibitors (e.g., grapefruit juice).
• Exercise Caution: Combining with other blood pressure medications.

Benefits for Fitness and Health

• Improves Sexual Health:
  • Enhances erectile function and orgasmic capability.
  • Slight reduction in sperm concentration due to increased ejaculation frequency.
• Fitness and Performance:
  • May reduce body fat and improve body composition.
  • Enhances glucose homeostasis and insulin sensitivity.
  • Increases androgen receptor content in muscles.
  • Improves total and free testosterone to estradiol ratio by lowering estradiol.
• Miscellaneous Benefits:
  • Not found to be lethal, carcinogenic, or teratogenic.
  • Potential benefits in mood and memory.

Side Effects

• Common:
  • Acid reflux (dyspepsia) especially when combined with oral steroids.
  • Headaches and dizziness.
• Management: Over-the-counter supplements and lifestyle changes can help alleviate side effects.

Fat Loss and Performance Enhancement

• Fat Loss Study:
  • Increases plasma free fatty acids and glycerol levels after administration.
  • No significant change in glucose levels, but improved insulin sensitivity.
• Performance Enhancement:
  • Potential for increased endurance and stamina.
  • Lack of conclusive evidence to warrant it being on anti-doping lists.

Dosage and Administration

• For Men:
  • Daily low dose of 2.5-10mg for consistent benefits.
  • 10-20mg pre-workout for enhanced performance.
• For Women:
  • 2.5-5mg pre-workout or daily.
  • 5-10mg for noticeable effects.

Conclusion

• Usage Advice:
  • Careful monitoring of side effects and interactions.
  • Potential to improve both gym performance and sexual health.
  • Continuous research needed to explore full benefits and minimize risks.

Personal Experience and Recommendations

• Speaker's View:
  • Personal experiments with dosages and combinations.
  • Positive anecdotal evidence on pumps and performance.

Note: Always consult with healthcare professionals before starting or changing any medication or supplement regimen.