hey guys it's medicos is perfection Ellis in previous videos we have discussed incompatibility and Rh incompatibility causing hemolytic disease of the newborn today we'll compare between the two first incompatibility is more common but less severe our age and compatibility on the other hand is less common but more severe incompatibility the mother is blood group O fetus can be blood Group A or B here the mother can be of any blood group mother is Rh negative fetus is Rh positive but blood group wise like a 4b or oh it doesn't matter first pregnancy can be affected no sensitization required here the first pregnancy is safe because we need previous sensitization hepatosplenomegaly is less common okay because it's less severe also unconjugated hyperbilirubinemia is less common jaundice is less common hemolytic anemia is less common connectors is less common reticulocyte ptosis is less common nucleated red blood cell presence in the blood smear isn't this common why because this is less severe on the other hand our agent compatibility all of these are more common now let's do the Coombs test here we have weekly positive direct Coombs test for the fear of red blood cells in the Rh incompatibility it's more severe so we have both direct and indirect Coombs both of them are strongly positive here we have Sphero sites here we have no Sphero sites why is that because the entire red blood cell is phagocytosis by the macrophages that's how severe this anemia can be okay quick note did you know that incompatibility can prevent the mother from developing our age sensitization yes indeed for example you can bring a white piece of paper and draw it on it imagine that Mommy is blood group O Rh negative and she's carrying a fetus who is blood group a Rh positive then any Rh positive fetal red blood cells entering her circulation will be destroyed by maternal anti a IgM agglutinins therefore preventing our age sensitization but beware incompatibility is not protective if the blood group O Rh positive red blood cells in the baby enter the maternal circulation that's it for today I'll see in the next video please subscribe