Overview
This lecture explains the harmful effects of smoking and tobacco use on the body, detailing the diseases and complications it causes.
Composition of Cigarettes and Smoke
- Cigarettes are made from tobacco leaves containing nicotine and many harmful compounds.
- Burning tobacco releases thousands of chemicals, over 40 of which cause cancer (carcinogens).
- Cigarette smoke contains poisonous gases like carbon monoxide and nitrogen oxide, and radioactive particles.
- All forms of tobacco (cigarettes, cigars, pipes, smokeless tobacco) are dangerous.
Effects of Nicotine and Addiction
- Nicotine is an addictive chemical that enters the brain and creates pleasurable sensations.
- Repeated nicotine exposure causes desensitization, leading to dependence and cravings.
Smoking-Related Diseases and Mortality
- Smoking is the leading cause of preventable death, responsible for 1 in 5 U.S. deaths.
- Major health risks include heart disease, heart attack, stroke, lung cancer, and chronic obstructive pulmonary disease (COPD).
Cardiovascular Effects
- Nicotine stimulates adrenaline release, which raises blood pressure.
- Nicotine and carbon monoxide damage artery walls, leading to plaque buildup (atherosclerosis).
- Atherosclerosis can cause coronary artery disease, increasing risk of heart attacks.
- Smoking promotes blood clots and increases risk of peripheral vascular disease and abdominal aortic aneurysm.
Effects on the Lungs and Airways
- Smoking damages bronchial tubes (airways) and alveoli (air sacs).
- Cigarette smoke irritates the airways, causing swelling, mucus, and slowed cilia, leading to "smoker's cough."
- Chronic bronchitis develops as cilia stop working, causing clogged airways and difficulty breathing.
- Damage to alveoli reduces oxygen exchange, leading to emphysema.
- Chronic bronchitis and emphysema are collectively called COPD.
- COPD is a progressive, incurable loss of breathing ability.
Cancer and Cellular Effects
- Carcinogens in smoke (e.g., cyanide, formaldehyde, benzene, ammonia) damage cell DNA.
- Damaged DNA causes abnormal cell growth and cancer.
- Lung cancer is the most common cancer globally, with over a million cases annually.
- Smoking increases cancer risk in many organs, including mouth, throat, esophagus, stomach, pancreas, kidney, bladder, uterus, and cervix.
Other Health Effects
- Smoking can cause infertility in both men and women.
- Smoking during pregnancy increases risks of low birth weight, miscarriage, pre-term delivery, stillbirth, infant death, and SIDS.
- Nicotine passes through breast milk, harming breastfeeding infants.
- Other effects include low bone density, higher risk of hip fracture (women), gum disease, immune dysfunction, delayed healing, and male impotence.
Key Terms & Definitions
- Carcinogen — a substance capable of causing cancer in living tissue.
- Nicotine — an addictive chemical found in tobacco.
- COPD — Chronic Obstructive Pulmonary Disease, a group of lung conditions including chronic bronchitis and emphysema.
- Atherosclerosis — hardening and narrowing of the arteries due to plaque buildup.
- Alveoli — tiny air sacs in the lungs where gas exchange occurs.
- Cilia — hair-like projections lining the airways that help clear mucus and debris.
Action Items / Next Steps
- Learn more about lung cancer screening at the provided link.
- Review the risks of tobacco use and share information to promote smoking cessation.