X-Linked Recessive Conditions

Overview

• X-Linked Recessive Conditions:
  • Result from gene variants on the X chromosome.
  • Typically affect males more severely as they have only one X chromosome.

Genetic Transmission

• Father's Genes:
  • Has an X-linked recessive condition.
  • Carries an altered gene on his X chromosome.
• Mother's Genes:
  • Has two usual forms of the gene on her X chromosomes.

Chromosome Inheritance

• Parents pass on one chromosome of each pair to their child.
• The combination is random, leading to four possible outcomes.

Possibilities for Children

• Daughters:
  • Inherit the father's X chromosome.
  • All daughters become carriers of the condition.
  • Potential to pass the altered gene to their offspring.
• Sons:
  • Inherit the father's Y chromosome.
  • Do not inherit the father's X-linked condition.
  • Cannot pass on the condition to their children.

Implications

• Daughters, as carriers, may pass on the condition depending on their partners' genetics.
• Sons remain unaffected and do not pass the condition to future generations.