Lecture Notes: Allulose and Its Effects on GLP-1

Introduction to Allulose and GLP-1

Allulose is a rare sugar that has gained attention for its potential health benefits.
GLP-1 (Glucagon-like peptide-1):
- Known for its role in weight loss drugs like semaglutide (Wigovi for weight loss, Ozempic for diabetes).
- Increases GLP-1, which is the mechanism behind popular weight loss drugs.

The speaker has a background in bioenergetics and has been involved in incretin research for nearly 20 years.
Initial skepticism about drugs for metabolic health, but recognizes potential benefits of GLP-1 mechanisms.

Delayed Gastric Emptying:
- Helps people feel fuller longer.
- Taking allulose before meals may control appetite and reduce cravings, especially in the evening.
Inhibition of Glucagon:
- Glucagon increases blood glucose levels, while insulin lowers them.
- Inhibition of glucagon helps control blood glucose levels, beneficial for diabetes management.
- Anecdotal evidence suggests improved glucose control in people with type 1 diabetes using allulose products.

Control of Glucose Entry:
- Delays gastric emptying and reduces glucagon levels, decreasing glucose entering the bloodstream.
Enhancement of Glucose Clearance:
- Activates AMPK enzyme, accelerating glucose breakdown and energy production.
- AMPK is the counterpart to mTOR, promoting energy usage by breaking down glucose.

Metabolic Benefits of Allulose:
- Creates a favorable metabolic environment by delaying gastric emptying, reducing glucagon, and increasing AMPK activity.
- These processes collectively help manage blood glucose levels and enhance energy metabolism.

Allulose shows promise in managing blood glucose levels by increasing GLP-1 and activating AMPK.
Benefits include delayed gastric emptying and glucagon inhibition, crucial for diabetes management.
Potential use of allulose as a dietary supplement for metabolic health.