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Brain Plasticity and Hemispherectomy

Sep 14, 2025

Overview

The lecture explores the brain's remarkable plasticity through the case of Jody Miller, a young girl who underwent a hemispherectomy to control severe seizures, demonstrating the brain's ability to adapt and recover.

Case Study: Jody Miller

  • Jody Miller developed severe epileptic seizures at age three, losing function on her left side.
  • Medicines were ineffective, and seizures threatened her life.
  • Doctors identified the seizures as originating from her right hemisphere, likely due to Rasmussen syndrome.
  • The surgical solution was a hemispherectomy—removal of her right cerebral hemisphere.

The Hemispherectomy Procedure

  • Hemispherectomy involves removing one cerebral hemisphere, which seems impossible but can be life-saving.
  • The brain's cerebral cortex is divided into two hemispheres, each controlling the opposite side of the body.
  • The surgery must avoid damaging areas responsible for life functions like heartbeat and breathing.
  • After surgery, the cavity left by the removed hemisphere fills with cerebrospinal fluid.

Brain Plasticity and Recovery

  • Brain plasticity is the ability of the brain to change structure and form new neural connections after injury or loss.
  • Jody's left hemisphere adapted to take over functions previously managed by the right hemisphere.
  • She was able to walk and function normally soon after surgery, with minimal paralysis left.

Ongoing Rehabilitation

  • Jody continues physical therapy to further overcome weakness or paralysis on her left side.
  • Continued brain training and stretching exercises are part of her recovery process.

Key Terms & Definitions

  • Epileptic Seizures — Sudden electrical disturbances in the brain causing changes in behavior or movement.
  • Rasmussen Syndrome — A rare, degenerative brain disorder causing seizures and loss of motor skills.
  • Hemispherectomy — Surgical removal of one hemisphere (half) of the brain.
  • Cerebral Cortex — The outer layer of the brain involved in higher functions like thought, movement, and sensation.
  • Plasticity — The brain's ability to adapt structurally and functionally after injury or changes.

Action Items / Next Steps

  • Review the definitions of brain plasticity and hemispherectomy for upcoming quizzes.
  • Read about other cases demonstrating brain plasticity for homework.