Prioritizing Differential Diagnoses in Assessment

Sep 3, 2024

Assessment of Reasoning Tool (ART)

Purpose

  • To assess a learner's ability to construct a prioritized differential diagnosis.
  • Focus on probability ranking based on problem representation.

Steps in Constructing a Prioritized Differential Diagnosis

  1. Select Leading Hypothesis
    • Choose the most probable diagnosis based on available evidence.
  2. Consider Can't-Miss Hypotheses
    • Identify serious or emergent diseases that must not be overlooked.
  3. Consider Less Likely and Unlikely Hypotheses
    • Evaluate alternative diagnoses that are less probable.

Problem Representation

  • A concise synthesis of the clinical problem.
  • Addresses three key questions:
    • Who is the patient?
    • What is the clinical syndrome?
    • What is the time course?
  • Compare potential diseases (illness scripts) with the problem representation.
  • Higher match increases the likelihood of a diagnosis explaining the patient's presentation.

Evidence in Diagnosis Ranking

  • Accompany diagnoses with clinical evidence that supports or refutes each possibility.
  • Include consideration for can't-miss diagnoses.

Evaluating Learner's Reasoning

  • Analyze spoken or written assessments for main problems.

Case Study Example

High Performer Example

  • Patient: Julio Martinez, 27-year-old woman, hyperthyroidism, two days of nausea, vomiting, diarrhea, left upper quadrant pain.
  • Most Likely: Viral gastroenteritis (nausea, vomiting, diarrhea, acuity).
  • Less Likely: Food poisoning (absence of illness in dining companions).
  • Unlikely: Appendicitis (location and diarrhea don't match).
  • Can't-Miss: Ectopic pregnancy (considered in young women with abdominal pain).
  • Note: Clear probability tiers and evidence for/against each condition.

Low Performer Example

  • Lists diagnoses: appendicitis, ectopic pregnancy, food poisoning.
  • Acknowledges emergent conditions but lacks probability delineation.
  • No evidence for or against diagnoses.

Summary

  • A prioritized differential diagnosis ranks diseases based on their match to the problem representation.
  • Must include can't-miss diagnoses.
  • Should articulate supporting and refuting evidence for each diagnosis.