now let's talk about sertoli cells and lighted cells and hormones okay so remember gonadotrope and releasing hormone is the hormone that um the hypothalamus is going to produce and it's going to act on the gematotrophs in the anterior pituitary and these guys produce two hormones to make produce follicle stimulating hormone and newtonizing formula okay so luteinizing hormone works on the lighted cells and that's one of the reasons I like using lighting because I can remember L and L this is going to stimulate them to produce testosterone okay testosterone has a lot of different effects that have nothing to do with spine okay testosterone it gives you the male form you know slim hips broad shoulders more body hair deep voice more muscle mass more red blood cells remember that um and there are other things to it it also increases libido we talked about that as well um so testosterone is important for a lot of different things and so testosterone uh is necessary all the time so guys to have a certain level of testosterone okay follicle stimulating hormone is going to work on these are totally cells but it works along with testosterone so both of these guys are required to make sperm okay let me change it's a little bit if you don't have testosterone you can't make sperm if you know my follicle stimulating hormone you can't fix phone you need both okay but remember testosterone has lots of other jobs this is not its only job follicle stimulating hormone this is its only job okay so what happens is um when levels of sperm production on high then so totally cells releasing heaven okay so in heaven is another hormone and so so totally cells are always releasing inhibit it's just how much inhibit um so I should really put at least more in heaven and in heaven acts on follicle stimulating hormone to decrease FSH levels but you don't want to mess up your testosterone levels because you need that you need that for the male secondary sex characteristics that make the male form you need that for lots of other things but if you're you don't want to be wasting your body is nothing if not efficient and you don't want to be wasting that on making sperm if you don't need it okay so when levels of sperm production are really high but still totally cells release more inhibit to decrease FSH levels now um when levels are low so totally cells release less inhibit so they control sperm production by how much inhibitin they release okay and that affects volatile stimulating hormone without affecting luteinizing hormone okay because if it affected if it just went and affected the hypothalamus it would affect the gonadotrope and releasing hormone which affects both of these guys well we don't want to affect both of them because we want to have that nice amount of testosterone that we need we just want to get rid of the excess FSH if we don't need it and the sertoli cells modulate the amount of follicle stimulating hormone there is by how much inhibit neighbor leaks they always release in heaven it's just the amount differs depending upon if there's lots of sperm or too little sperm all right so if a man is ejaculating more you need more sperm if he's ejaculating less you need less sperm and follicle stimulating hormone controls the level of spermis produced and that's modulated by inhibit that's released by the sertoli cells okay all right I'm going to hesitate here for a moment so that anybody that wants to take a picture of this can as well one other thing about this um to some of the testosterone is converted into a more potent form called DHT which is dihydro testosterone you're so you know what DHT is so some of it this is a more potent form I actually um the last project I worked at The Med Center I was working on DHT and um it was a very interesting project there's more DHT people who have more DHT tend to have um problems they can connect high levels of DHT to prostate cancer high levels of DHT with severe acne and that was actually what I was working on the acne portion of it um trying to develop something to inhibit DHT in a cream sort of form that could be used as topically to treat acne okay um my last my last gig as a as a post office with a dermatologist who worked in the cancer center because this was connected to cancer that was one of the things I did I worked for parsley for a pharmaceutical company okay so I'm gonna hesitate for a second in case anybody wants to take a picture and then we're going to move on