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PICO Method for Clinical Questions

Oct 25, 2025

Overview

This lecture introduces the PICO method for formulating clinical questions in nursing, focusing on the five main types of PICO questions and their templates.

Introduction to PICO Method

  • PICO is a mnemonic for building effective clinical foreground questions.
  • Foreground questions target specific clinical issues, unlike broad background questions.

Elements of PICO

  • P: Population/Problem — describes the patient group or condition.
  • I: Intervention — main treatment, exposure, or therapy under consideration.
  • C: Comparison — alternative intervention or control (if applicable).
  • O: Outcome — desired results or effects.

Types of PICO Questions & Templates

  • Intervention Questions: Determine which treatment gives the best outcome.
    • Template: In [population], how does [intervention] compared with [comparison] affect [outcome]?
  • Etiology Questions: Identify causes or risk factors for a disease.
    • Template: Are [population] who have [risk factor] compared with those without [risk factor] at [outcome] risk for [disease]?
  • Diagnosis Questions: Find which test most accurately diagnoses a condition.
    • Template: In [population], is [test 1] compared with [test 2] as good at diagnosing [disease]?
  • Prognosis / Prediction Questions: Predict likely outcomes of a condition or treatment.
    • Template: In [population], does [intervention] compared with [comparison] predict [outcome]?
  • Meaning Questions: Understand the meaning of an experience for a patient or group.
    • Template: How do [population] with [condition] perceive [phenomenon]?

Key Terms & Definitions

  • PICO — A framework for structuring clinical research questions (Population, Intervention, Comparison, Outcome).
  • Foreground Question — A focused question aimed at finding evidence for a specific clinical scenario.
  • Background Question — A general knowledge question about a condition or topic.
  • Intervention — Treatment or action considered for the patient/group.
  • Etiology — Study of causes or origins of disease.

Action Items / Next Steps

  • Practice drafting different types of PICO questions using the provided templates.
  • Watch video 3 for more examples and practice with the PICO method.