The heart has four chambers. Two upper chambers, the right and left atrium, and two lower chambers, the right and left ventricles. Fibrillation describes when the muscle fibers are all contracting at different times, so the end result is this quivering or twitching movement. Normally an electrical signal is sent out from the sinus node in the right atrium.
It then propagates out through both atria super fast, which allows them to all depolarize at about the same time. and you end up with this nice coordinated contraction of the atria. That signal then moves down to the ventricles and causes them to contract shortly after. With atrial fibrillation, or afib, or sometimes af, signals move around the atria in a completely disorganized way that tends to override the sinus node. Instead of one big contraction then, you get all these mini contractions that make it look like the atria are just quivering.
On an electrocardiogram, or ECG, Normally the P wave corresponds to the atrial contraction, which is followed shortly after by the QRS complex, which is the ventricular contraction. During AF all these small areas are contracting at different times, so you end up with this scribble sort of looking ECG, each little peak corresponding to one spot in the atria twitching. Sometimes a signal from one of these areas make it down to the ventricles and cause ventricular contraction.
These contractions and QRS complexes are interspersed at irregular intervals though, and usually at fairly high rates between 100 and 175 beats per minute. In the normal heartbeat, a well-coordinated atrial contraction does contribute a small amount of blood that's called the atrial kick. People with AF lose this atrial kick, although this loss isn't life-threatening. Okay, but how or why does this happen in the atrium?
Why do the cells start depolarizing in a totally uncoordinated way? Well, the answer isn't super cut and dry. There are a ton of risk factors that predispose someone to developing AF, and the exact mechanisms aren't well understood. AF often happens alongside other cardiovascular diseases, like high blood pressure, coronary artery disease, valvular diseases, essentially anything that can create an inflammatory state or physically stretch out the atria and potentially damage the cells in the atria.
Other non-cardiovascular risk factors include obesity, diabetes, and excessive alcohol consumption. Adding to all this, there also seems to be a genetic component as well. These factors likely stress the cells in the atria, which can lead to tissue heterogeneity, which means that the cells start taking on different electrical properties.
For example, this cell might start conducting signals faster than its neighbor, and that cell might develop a shorter refractory period, which is the time following a depolarization that they can't conduct another signal. These different tissue properties can ultimately cause the conduction in the atria to become unpredictable. Normally, with tissue that's the same, you'll get essentially one wavefront of conduction that moves through the atria. With different tissue properties, multiple wavelets are thought to develop, called the multiple wavelet theory. These wavelets conduct randomly around the atria, sometimes colliding and creating new daughter wavelets.
Along with this multiple wavelet theory, There's also an automatic focus theory, where there's a specific origin that's thought to initiate AF by rapid firing of electrical impulses that overtake the sinus node. And combined with the risk factors and tissue heterogeneity, this can promote AF, and it's thought that the focus of cells are conducting cells in the cardiac muscle around pulmonary veins. Yeah, pulmonary veins.
Remember that these veins physically enter the left atrium. And where the pulmonary veins enter, there's this tissue that has really unique electrical properties. Oftentimes people with AF start with what are called paroxysmal events, which means AF suddenly comes and goes, lasting less than a week at a time, probably because the tissue is still relatively healthy.
Repeated paroxysmal events that occur over longer periods of time though tend to stress the atrial cells even more. There are probably a number of mechanisms explaining how a burst of rapid beats from one of these paroxysmal events leads to stress, but one potential mechanism is through calcium overload. Nonetheless, over time, the cells in the atrium seem to undergo progressive fibrosis or scarring from this stress. When this happens, the AF episode isn't able to spontaneously terminate, and patients have persistent AF, defined as lasting more than a week without self-terminating. Persistent AF episodes can last for quite a long time, weeks to months.
And when the AF episodes last beyond 12 months, it's known as a long-standing persistent AF. And permanent AF is what it's called when the patient and the clinician make a joint decision to not attempt to stop the rhythm. Common symptoms of AF are feelings of general fatigue, since the heart rate isn't being governed by the sinus node anymore, and contracts at irregular intervals, delivering blood less effectively to the tissues. Other related symptoms include dizziness, shortness of breath, and weakness.
Patients might also feel palpitations or a thumping in their chest. One potential complication of AF is stroke. When the atria don't contract as a single unit, but just sort of quiver, The blood that sits in the atria becomes more stagnant.
When blood stays still, it tends to form clots. With AF, it's possible that blood clots form, which then travel into the ventricle and are pumped off to the body, and potentially to the brain, where they can lodge. This cuts off blood flow to that part of the brain, which is a type of stroke.
Now, diagnosis of persistent AF is done by ECG. Although if the episodes are paroxysmal, but they're suspected, then someone might have a Holter monitor. which is a portable device placed on the chest that monitors their rhythm over longer periods of time and records potential AF events to be viewed later. Since AF is caused by such a diverse range of issues, treatment is generally different from patient to patient. Certain medications that help control the heart rate might be given, or medications that reduce the likelihood of blood clot formation and therefore prevent stroke.
Also, patients might receive an implantable cardiac pacemaker. which, by constantly pacing the atrium, can reduce the chance of an AF episode. Finally, some patients might have a radiofrequency catheter ablation, where certain areas of tissue are destroyed such that the electrical signal doesn't propagate anymore. One type of procedure is the maze procedure, where a maze of new pathways are created to help electrical signals move in a more consistent and predictable pattern. Sometimes, patients will have ablation of their AV node, essentially cutting off any communication between the two.
Since the ventricles aren't getting any input anymore though, these patients need an implantable pacemaker to make sure the ventricles contract at high enough rates. You can help support us by donating on Patreon, or subscribing to our channel, or telling your friends about us on social media.