Trenbolone Acetate Lecture Notes

Overview

Trenbolone Acetate is an androgen and anabolic steroid (AAS) used in veterinary medicine.
Promotes muscle growth in cattle to increase livestock profitability.
Administered via intramuscular injection.

Clinical Data

Trade Names: Finajet, Finaplix, others.
Other Names: RU-1697, Trenbolone 17-acetate, 19-Nor-9,11-testosterone 17-acetate.
Drug Class: Androgen, Anabolic steroid, Androgen ester, Progestogen.
Elimination Half-Life: 3 days intramuscularly.

Chemical Data

Formula: C20H24O3
Molar Mass: 312.409 g/mol
Identifiers: CAS number 10161-34-9, PubChem CID 66359, DrugBank DB14660, ChemSpider 17468428, UNII RUD5Y4SV0S, ChEMBL1698011.

Uses

Primarily used in cattle to enhance muscle growth before slaughter.
Occasionally used by athletes and bodybuilders for physique and performance enhancement, though not approved for human use.

Side Effects

Masculinization Symptoms: Acne, increased body hair, scalp hair loss, voice changes, increased libido.
Cardiovascular Issues: Negatively impacts cholesterol levels, suppresses HDL, increases LDL.
Specific to Trenbolone Acetate: Oily skin, seborrhea, accelerated hair loss, virilization in women.

Pharmacology

Mechanism: Agonist of the androgen receptor (AR).
Effects: Strong anabolic and androgenic effects, potent progestogenic effects, weak glucocorticoid effects.
IGF-1 Production: Enhances muscle recovery and growth.
Red Blood Cell Count: Increases RBC count, enhancing blood oxygenation and endurance.

Administration

Commonly administered as a subcutaneous implant in the posterior ear of cattle using an implanter gun.
Dosage form includes pellets containing 20mg of trenbolone acetate.

Legal and Societal Aspects

Use outside veterinary contexts is controlled and often illicit.
Banned by major sporting and bodybuilding organizations.
Legal variations exist between countries regarding personal use and distribution.

Historical Context

Discovered in 1963 and introduced for veterinary use in early 1970s.
Not approved for human use, yet popular in bodybuilding circles for its non-estrogenic benefits.
Marketed under various names for veterinary uses, often combined with estradiol.

Structure and Activity

Modified form of nandrolone, lacks a carbon atom at the 19 position, with double bonds at carbons 9 and 11.
The acetate ester causes slow release post-injection, allowing for a longer active period.
Related to other trenbolone esters like trenbolone enanthate.

These notes summarize key information about trenbolone acetate, covering its uses, effects, side effects, and legal and societal implications. It is crucial for veterinary applications but has significant use in bodybuilding and is subject to legislation and control due to its potent effects.

Understanding Trenbolone Acetate