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Differences Between SIADH and Diabetes Insipidus

May 6, 2025

Lecture Notes: SIADH vs. Diabetes Insipidus

Presenter: Sarah from RegisteredNurseRN.com

Overview

  • Discusses the differences between Syndrome of Inappropriate Antidiuretic Hormone (SIADH) and Diabetes Insipidus (DI).
  • Emphasizes understanding Antidiuretic Hormone (ADH) functions to comprehend these conditions.
  • Encourages taking an online quiz to test knowledge of the material.

Key Concepts

Antidiuretic Hormone (ADH)

  • Also known as vasopressin.
  • Regulates water balance in the body and constricts blood vessels.
  • Works with kidneys to retain or release water.
  • Produced by the hypothalamus, stored and secreted by the posterior pituitary gland.

SIADH

  • Characterized by: Increased ADH.
  • Causes: Damage to hypothalamus or posterior pituitary, lung cancer, infections (pneumonia, meningitis), Guillain-Barré Syndrome, and certain medications.
  • Symptoms: Water retention, fluid overload, weight gain, high blood pressure, tachycardia, hyponatremia, confusion, anorexia, low urine output with high urinary specific gravity.
  • Nursing Interventions: Fluid restriction, monitoring daily weights, strict intake and output.
  • Medical Treatments: Loop diuretics (watch for hypokalemia), hypertonic IV solutions, Demeclocycline (inhibits ADH).

Diabetes Insipidus (DI)

  • Characterized by: Decreased ADH.
  • Causes: Kidney issues, medications, pregnancy, brain trauma.
  • Symptoms: Excessive urination, dehydration, dry skin, hypotension, dilute urine.
  • Nursing Interventions: Avoiding diuretic foods and beverages (caffeine, watermelons, etc.).
  • Medical Treatments: Diabinese (watch for hypoglycemia), Desmopressin (ADH replacement, watch for hyponatremia).

Comparative Summary

  • SIADH: Increased ADH leads to fluid retention, requires fluid removal.
  • DI: Decreased ADH leads to fluid loss, requires fluid replacement.

Study Recommendations

  • Review key points from the lecture.
  • Take online quizzes to reinforce knowledge.
  • Remember the mnemonic for SIADH and DI (I for Increase in SIADH to help differentiate).
  • Focus on understanding how ADH affects the body to grasp the conditions better.