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Which hormone is secreted by somatostatinoma and what are its inhibitory effects?
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Somatostatin; inhibits multiple hormones
From which cells do functional pancreatic neuroendocrine tumors arise?
Endocrine pancreas (islet cells of Langerhans)
What hormone is secreted by a gastrinoma, and what syndrome is it associated with?
Gastrin; Zollinger-Ellison syndrome
What is Whipple's triad, and which type of pancreatic tumor is it associated with?
Hypoglycemia, symptoms of hypoglycemia, symptom relief with glucose; associated with Insulinoma
Which type of pancreatic tumor is known for causing explosive watery diarrhea, and what syndrome is it associated with?
VIPoma; Verner-Morrison syndrome
What are functional pancreatic neuroendocrine tumors also known as?
Islet cell tumors
Which tumors aside from the main functional pancreatic neuroendocrine tumors are less common?
ACTH-oma, CRH-oma, Calcitonin-oma, CRF-oma, Parathyroid hormone-related peptide tumors (PTHrP)
How are functional pancreatic neuroendocrine tumors generally treated?
Somatostatin (octreotide), surgical resection
What are the hallmark signs of an insulinoma?
Hunger, nervousness, sweating, lethargy, confusion, coma
What characteristic differentiates VIPoma diarrhea from other diarrhea types?
Explosive watery diarrhea, low hydrochloric acid, low potassium, dehydration
What clinical symptoms are characteristic of glucagonoma?
Mild diabetes, dermatitis (necrolytic migratory erythema), weight loss, anemia, venous thrombosis (DVT)
What defines secretin's role in diagnosing gastrinoma?
Gastrin levels are not suppressed by secretin in patients with gastrinoma
Describe the symptoms of a patient with somatostatinoma.
Mild diabetes, gall stones, steatorrhea, hypochlorhydria (low hydrochloric acid)
Which pancreatic neuroendocrine tumor is mainly diagnosed by increased glucagon levels in blood?
Glucagonoma
What is the relevance of MEN1 in relation to pancreatic tumors?
Multiple Endocrine Neoplasia type 1 (MEN1) can be associated with some pancreatic tumors
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