Effects of Combining Marijuana and Alcohol

Overview

• Marijuana and alcohol are commonly used together.
• They have both distinct and combined effects on the body and brain.

Effects on the Brain

• Alcohol:
  • Affects central nervous system by altering neuron communication.
  • Suppresses excitatory neurotransmitter glutamate.
  • Increases inhibitory neurotransmitter GABA.
  • Results in slower information flow, reduced perception, and memory impairment.
• Marijuana:
  • Contains THC, which acts on brain's cannabinoid receptors.
  • Causes continuous neuron firing, amplifying thoughts and imagination.
  • Also inhibits glutamate transmission, affecting learning.

Combined Effects

• Both substances inhibit glutamate transmission, worsening memory.
• Study Findings:
  • Rats showed impaired object recognition when both drunk and high.
  • Human studies showed increased THC levels after consuming alcohol.
  • Participants reported a quicker, more intense high with alcohol.
  • Alcohol increases THC absorption through vasodilation (blood vessel widening).

Alcohol and THC Interaction

• Alcohol increases blood flow, allowing more THC to enter the bloodstream.
• Results in an enhanced high and mood.

Marijuana's Protective Role on the Liver

• Ethanol Metabolism:
  • Alcohol is metabolized by cytochrome P450-2E1 enzyme.
  • Excessive drinking leads to oxidative stress and liver damage (steatosis).
• Cannabidiol:
  • Found to inhibit oxidative stress cycle, protecting liver cells.

Health Risks

• Marijuana prevents vomiting, which can be dangerous in alcohol poisoning.
  • Vomiting helps expel excess alcohol, preventing poisoning.

Conclusion

• While marijuana may reduce some alcohol-related liver damage, the combined use poses risks, particularly in terms of memory impairment and alcohol poisoning.
• Further research is needed to fully understand the health implications.

Additional Resources

• Check out the drug video playlist for more information on different drugs and their effects on the body and brain.
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