Antifungal agents. Antifungal agents we would give for patients that are susceptible to maybe a fungal organism such as Candida, coccidioids which would be Valley fever, Aspergillus that's another type of respiratory illness if they inhale spores and then there's multiple sites of infection so there could be oral, esophageal, skin, pulmonary, vaginal or systemic. Side effects, headache, nausea, vomiting, liver and renal dysfunction, toxicity, and then amputarism B. Amputarism B is one of the prototypes we need to remember. So specific for that side effect wise, the patient could have fever, they could have shivering, sorry, renal or neurotoxicity, and maybe even cardiac dysrhythmias.
So precautions would be for renal or liver impairment. and this also could have many drug interactions contraindicated in liver failure because of metabolism how the drug is metabolized so nursing actions we're going to follow those lfts if we're worried about liver failure we should be looking at liver function right or um even if it could cause just liver impairment so lfts butane and creatinine so we're looking at those kidneys we're going to make sure that we ensure appropriate pre-medication as indicated So because of the side effects, which we saw some of the side effects of antifungal agents could be the headache, nausea, vomiting, those types of things, we could probably pre-medicate the patient to help combat some of those side effects. So maybe we can give them an antipyretic to help reduce fever and antihistamine, anti-emetics to help with the nausea, vomiting, and then maybe even corticosteroids.
So that'd be pretty common to help basically just decrease the severity. of any type of infusion-related reactions. Typically, you see these symptoms more or less when the patient's getting them IV. So examples of drugs in class, fluconazole, ampotaricin B, nystatin, ketoconazole, and boric, oh, you don't have to remember the last one, sorry, ketoconazole.
Those are the prototypes you need to remember. I'm trying oh so for the amphotericin B we give that IV and we would give that for cryptococcal meningitis um not something you have to remember for for testing but that's one of the indications for that nystatin so with the nystatin we would give if a patient had a fungal infection that could either be oral topical or vaginal so an example for oral will be thrush I don't know if you've seen any babies where they get the white coating on their cheeks roof of their mouth and even their tongue it's pretty painful they don't want to eat that is an example of maybe a reason why we would give oral nice down to a kiddo okay so