Cross-regulation between the Nervous System and Type 2 Immunity

Introduction

• Interactions between the nervous and immune systems are integral to maintaining healthy physiology.
• Disruptions in these interactions are linked to various human diseases.

Type 2 Immune Responses

• Involves type 2 lymphocytes, cytokines, mast cells, and immunoglobulin E.
• These components are crucial for neuronal function and behavior.

Nervous System Influence

• Both central and peripheral nervous systems can modulate type 2 immune responses.
• Neuronal influence affects behaviors related to allergies, such as food avoidance.

Therapeutic Potential

• Understanding the nervous-immune system circuit could aid in developing immunomodulators for neurological diseases.
• Diseases potentially affected include Alzheimer’s disease, brain injury, and neurodevelopmental disorders.
• Modulating the nervous system may also aid in treating immunological disorders like atopic dermatitis, asthma, and food allergies.

Recent Work

• This review highlights recent findings on how nervous system regulation is influenced by type 2 immune responses.

Authors and Affiliations

• Nicholas M. Mroz - Biomedical Sciences Graduate Program, University of California, San Francisco.
• Pailin Chiaranunt - Department of Laboratory Medicine, University of California, San Francisco.
• Anna V. Molofsky - Department of Psychiatry and Behavioral Sciences, University of California, San Francisco.
• Ari B. Molofsky - Department of Laboratory Medicine, University of California, San Francisco.

Funding

• Supported by the National Institute of Neurological Disorders and Stroke (1R01NS126765).
• Additional support from Schmidt Science Fellows in partnership with the Rhodes Trust.

Conclusion

• A comprehensive understanding of the interplay between the nervous and immune systems could lead to novel therapeutic approaches for both neurological and immunological conditions.