[Music] hey everybody this is Hunter Williams I hope you're doing amazing wherever you are out in the world today's video is going to be about tadalfil AKA Calis for longevity now most of everyone knows that Calis or tadalafil is for erectile dysfunction but not as many people realize it's actually one of the more potent and Power ful anti-aging SL longevity medications or drugs that are available to us today so what I want to do today is examine all of the anti-aging benefits of tadalfil and uh not only does it help with the rectile dysfunction but it's also just good to have in your anti-aging stack uh obviously for men it's good but I think women can definitely use it too so what I'm going to do today is just provide a comprehensive guide and overview to the use of tadalfil for anti-aging and Longevity so hopefully you understand a little bit more and just understand that it's not the uh I guess what do they call it the little blue pill or something like that uh that people use it can be used for that but um it's also at a different dose very very effective for anti-aging on longevity and that's what we're going to get into today is uh how those mechanisms work in the body so uh before I do that just remember that you can always sign up for the peptide Chi down below teaches you everything you need to know about peptides to get started and then also too if you enjoy topics like this head over to the private membership group fully optimized Health Link is always down in the description it's $99 a month you can cancel any time but we do live calls every Tuesday night and also have an amazing forum and group in there where you can ask any of your questions around peptides hormones anti-aging longevity all that stuff and that's what J Campbell and I so without further Ado I'm going to share my screen and today we're going to look at tadalafil for anti-aging and Longevity all right so this is tadalfil for longevity and a comprehensive guide to tadalfil and Calis so let's jump into it so what is tadalfil so let's get into an actual overview so basically it is primarily to used to treat erectile dysfunction BPH and Pa pah in men which are common in aging men so its mechanism of action involves inhibition of pd5 leading to increased levels of cgmp and improved blood flow so emerging research suggests that Tata fil may have anti-aging effects including in improved lifespan increased cognitive function and reduced inflammation and then obviously too uh this is where it's going to be really impactful is um this mechanism of action has been shown to improve blood flow and reduce inflammation which can have positive effects on cardiovascular heart health and Urological Health as well so what does uh this mean with pd5 inhibition and the CGM MP pathway bunch of letters what does that actually mean so pde5 stands for phosphodiesterase type 5 an toil inhibits this which is an enzyme responsible for breaking down cyclic guanosine monophosphate otherwise known as cgmp so by inhibiting pd5 to doil increases cgmp levels in the body now why is that beneficial so basically elevated cgmp enhances the effect of nitric oxide which is a key vasodilator this is why it works well for erectile dysfunction so nitric oxide is produced by endothelial cells and diffuses into smooth muscle cells where it activates guelat leading to increased cgmp production now higher cgmp levels result in a relaxation of smooth muscle cells in the blood vessels leading to ve vasod dilation increased blood flow so when we look at cardiovascular health heart health all those things that are a huge marker of longevity obviously cardiovascular disease is the number one killer of people in the first world today uh it's because we end up having poor endothelial function meaning that our blood vessels are constricted and they're blocked and we are not able to pum pump blood through them so um let's look at heart health why does this matter for heart health so TOA basically improves indal function by increasing nitric oxide availability and reducing oxidative stress so this helps maintain vascular health and reduces the risk of atherosclerosis or heart disease um basically there's a lot also coming out too about nitric oxide and cholesterol in the body and my opinion is I think this has something to do with the oxidation of fats that would end up causing what we know to be high cholesterol but we increase nitric oxide availability it reduces the oxidation and oxidative stress thereby helping make us healthier helping us have healthier vascular networks also by reducing inflammatory markers such as C reactive protein and tumor necrosis Factor alpha or tnf Alpha toil contributes to cardiovascular heart protection so very powerful in that sense now let's look at mitochondria function I think if we knew one thing about our health is that the mitochondria are basically like what regulate our energy so aside from just helping with blood flow how does tadalfil improve mitochondrial function so it basically enhances mitochondrial biogenesis through the cgmp PKG pathway which activates something called peroxisome proliferator activ activated receptor Gamma co-activator 1 Alpha or PGC 1 Alpha a lot easier to say that which is a master regulator of mitochondrial biogenesis also by improving mitochondrial function and reducing oxidative stress tadalfil helps maintain cellular energy production and reduce cellular agent so when we look at the mechanism by which talil works it improves the health of the mitochondria which is going to help the cell get energy into it more efficiently kind of think about it as an old car an old car may burn oil more properly or prob may burn oil um at a much more staggering rate so like for instance um I had this old car one time and I would have to put oil in it like every few days because it was leaking oil and uh it was really really old but um we improve all of these systems in the body it's going to make us get more gas mileage so to speak and we don't have all these leaky buckets of things that are kind of causing problems so by improving cellular industry production it reduces the Aging of the cell which is obviously going to help us from an anti-aging longevity standpoint now let's look at exercise health I think it's much more underrated to use tadalfil for exercise performance which is why I believe it's actually a ban substance in most Pro Sports but basically tadalfil increases blood flow to skeletal muscles which enhances oxygen and nutrient delivery delivery which improves Exercise capacity of muscle function so basically by all the mechanisms that we just talked about it enhances the ability of oxygen and nutrients to get to the muscle to help with muscle repair uh which is going to improve our Exercise capacity and muscle function and I can attested this personally if I used to Dill right before workout I have an amazing workout if you go to the gym you have amazing pumps but even if I use it before cardio I feel like I can go forever and it's because of this increased Exercise capacity um the enhanced circulation also reduces inflammation and AIDS in Muscle Recovery reducing exercise induced muscle damage so it helps us basically recover faster so it's definitely something that we can use uh to great effect for performance you know alongside other things now especially as it relates to anti-aging and Longevity let's look at cognitive function so talil improves blood flow to the brain which enhances oxygen and nutrient delivery to neuronal tissues so as it is doing to our muscles it's also doing it to our brain so if we're getting extra oxygen to the brain it's going to help support all those different areas of the brain that support cognitive function so this can support our cognitive function and reduce the risk of neurodegenerative diseases so again by reducing oxidative stress and inflammation in the brain tadalfil may protect against cognitive decline what we know now too about Alzheimer's and Dementia and it's really type three diabetes of the brain so tadalfil basically is helping reduce some of this oxidative stress that is coming as a result of the uh effect of diabetes in the brain and reducing inflammation which again is going to protect against cognitive decline so um I definitely noticed probably more of like a mental stimulation too from tadalfil even at a relatively small dose uh I'm going to get to the dosing later but it definitely helps with brain function and especially as we're aging that's one thing that I think everyone should be on guard against now let's look at metabolic health so this is actually um uh I think bigger Steve shout out to biger Steve talked about uh how tadala has actually been shown to have huge um benefits as far as metabolic health so let's look at insulin sensitivity obviously aging is a result of insulin sensitivity and um inflammation in the body so tadalfil improves insulin sensitivity by enhancing indial function and reducing inflammation so this helps regulate blood glucose levels and mitigate age related metabolic disorders so obviously the more insulin sensitive we are the better we're going to live life to the fullest and obvious ly to reduce any of those age related diseases uh it also helps with adaptin levels so tadalfil may increase adaptin which is an anti-inflammatory ocine that improves insin insulin sensitivity and metabolic health so as it relates to Fat Loss I'm not saying if you take a small dose of tadalfil that you're going to melt fat like crazy but it is absolutely an agent that can be used in support of fat loss if you're doing everything right um to help give you an extra boost and Edge if assuming you're doing everything right listen at pulmonary health so basically by promoting vas vasodilation in the pulmonary Aries arteries tadalfil reduces pulmonary vascular resistance and improves oxygenation which is beneficial for pulmonary hypertension which is high blood pressure and overall respiratory health so again this is one of those things that uh as far as high blood pressure goes tadalfil works really really well um amongst other things I.E diet lifestyle and cardiovascular exercise to help improve hypertension and high blood pressure now here's the big one because this is where it really kind of hits home for most men is prostate health so most men will deal with age related prostate issues it's inevitable luckily and fortunately I have not experienced that myself yet but I think it's one of those things that every man kind of knows is coming or is experiencing it for themselves so uh talil is huge as relates to pred health and I want to do a little bit more of a deep dive into this so basically to go back to this IDE a of smooth muscle relaxation uh talil induces smooth muscle relaxation in the prostate and bladder neck through the inhibition of pde5 which leads to increased levels of cgmp like we talked about so this mechanism is similar to the effect of alpha blockers commonly used in medications for BPH which is benign prostate hyperplasia um it also reduces ureth urethal resistance so the relaxation of smooth muscle decreases urethal resistance making it easier to urinate and reducing the severity of lower urinary tract symptoms um also when we look at blood flow around the prostate so prostate and uh bladder neck blood flow tadalfil is going to enhance blood flow to the prostate and badder neck to improve oxy oxygenation and nutrient delivery to these tissues this can help maintain healthy tissue function and reduce symptoms associated with BPH um it also improves circulation and can help reduce inflammation in the prostate which is often associated with BPH and uh lower urinary tract symptoms also uh to go to those urinary tract symptoms clinical studies have demonstrated that tadalfil can significantly improve these symptoms in men with BPH so these symptoms include urinary frequency urgency nocturia weak urine stream and incomplete bladder emptying which I think all men have experienced and unfortunately older men experienced that at a greater rate um and copil is also used to treat erectile dysfunction its dual action can be particularly beneficial for men that both experience BPH and D Ed which is very common to have um which are conditions that often coexist in aging men so continuing with prostate health um it also reduces prostatic inflammation so the anti-inflammatory effects extend the prostate reducing levels of inflammatory pyocin and other inflammatory markers with the prostate issue and then also too by reducing inflammation tadalfil may help decrease prostate size or slow its progression improving urinary symptoms and then obviously too we have sexual health so talo improves erectile dysfunction which can have a positive impact on overall sexual health and quality of life and this is important as sexual dysfunction is commonly associated with BPH and can exacerbate symptoms and obviously too there's the psychological benefits of sexual health Improvement um so reduction in urinary tract symptoms can lead to better mental health and reduced anxiety depression often in men with BPH especially as it relates to Performance and anxiety for men and their Partners now let's get into everyone's favorite part the dosage Administration so when we're looking at this in the context of anti-aging longevity I'm not talking about the use of specific erectile dysfunction for specific days that you would need it um the optimal dosage for anti-aging and Longevity is kind of up in the air right now as it relates to clinical literature but in my experience it's going to be somewhere around 2.5 to 5 milligrams now men may need to go up to 20 milligrams but I'm going to see I'm going to say that's much more of a erectile dysfunction use case um but lower doses are more effective in the long term for cardiovascular metabolic benefits so obviously to we have the treatment of BPH to dofil is often prescribed at a daily dose of 5 milligrams which is on the lower side so it's effective for um managing some of those urinary tract symptoms associated with BPH uh but without getting into too high of a dosage so it seems to be that 2.5 to 5 milligrams is The Sweet Spot uh for the long term and to especially be the minimum effective dose to help alleviate some of those symptoms now here is kind of of where you have to be smart with tadalfil because you do need to cycle it and I wish you could use it every day at the same dose and get the same effect but un unfortunately that's not the case so let's look at the cellular attenuation associated with tadalfil so continuous use of tadalfil can lead to receptor downregulation where the body reduces the number of available receptors in response to prol prolonged exposure to the drug so this can diminish the effectiveness of talil over time basically that leads to desensitization which means that the persistent stimulation of the cgmp pathway by toil can result in desensitization of this pathway which reduces the drugs impact on smooth muscle relaxation and baso dilation basically long story short is the more you use the more you've got to up the dose um to get the same effect and this is where uh cycling is going to come in so cycling on and off can help prevent the development of Tolerance ensuring that the medication remains effective over the long term which is obviously what we want so regular breaks allow the body's receptor systems to reset maintaining the drugs therapeutic benefits and periodic cycling can optimize the anti-aging cardiovascular and prostate health benefits of tadalfil by preventing this cellular ten attenuation and overall sustaining its efficacy so what does that look like well my on cycle would be the following and you probably skipped it his right here if you just wanted the good medy part without all of the foreplay but um on cycle a typical on cycle usually involves daily or every other day use for a period of 4 to 8 weeks depending on the individual response I would say the older you are typically the longer you should run it at a daily dose and then an off cycle of two to four weeks can help reset receptor sensitivity and maintain the drugs Effectiveness so during this period monitoring for any changes in symptoms or health status is crucial so obviously there's no one- siiz fits-all approach but I would say you know four to eight weeks on and then two to four weeks off you could even do one week on and one week off but I think the older you are the more you may be dealing with prostate or BPH issues uh the longer you can run it and the shorter you could take off but for someone that's may be in their 30s or 40s that doesn't really have any of those issues you could probably do it for one week on or one week off or two weeks on and two weeks off and then kind of use it as needed if you had erectile dysfunction in the meantime so that would be my suggested cycling protocol um at the end of the day again it's all about maintaining receptor sensitivity to it and whether you know you're 80 and you're trying to um you know help with prostate issues and help with erectile dysfunction issues or you're 30 and you're just using it for maybe performance enhancement in the gym or something like that you got to take at least some time off and I know that's not the funnest thing to do but again to go back to what I talk about all the time with peptides if you want the peptides to work you got to be smart about how you cycle it to Dills unfortunately because of the phaco kinetics and pharmaco dynamics of it not really any different so that is it for the slides and that is the comprehensive guide to toil so hopefully that was helpful for you I really think you know if I could probably choose like you know five to 10 different peptides drugs medications or something like that I would put talil in in far as so far as an anti-aging stack a longevity stack is concerned um it's just oftentimes overlooked now I did mention that women could potentially use this um I think for women you'd probably want to stay somewhere around two and a half milligrams um but obviously the whole thing with the prostate is not something women necessarily struggle with their issues are going to be different uh but you can still get the performance enhancement benefits um from tadalafi as a woman uh you just need a lower dose of like 2.5 milligram so I did want to throw that in there before I closed out the video but hopefully that was helpful to you guys hopefully this made sense and you can kind of take it now and run with it um obviously this would be something you go through your doctor to get so talk to your doctor most doctors are actually pretty good about prescribing this and it's pretty cheap relatively speaking um as far as you know pharmaceutical medications go so as always leave your comments questions concerns below and I will make sure I do my best job to answer those or if I was wrong about something definitely feel free to uh correct me down below um you know I always want to say I have no ego invested even though that's hard to say um for all of us but uh I want to say have no way you go invested because it's more about the material and teaching people the right thing to do so they can optimize their health and live long and strong so appreciate you guys much love don't forget to sign up for the email list and check out fully optimized Health the group if you like topics like this and I will see you in the next one peace