Ondansetron (Zofran) - NCLEX Review

Introduction

• Ondansetron (brand name: Zofran)
  • Used to treat nausea and vomiting
  • Common in hospitals
  • Know the generic name for NCLEX: Ondansetron

Memory Anchor

• Visualization: Dancer on stage (Dancer = Ondansetron)

Use Case

• Treats nausea and vomiting
  • Post-operative nausea
  • Chemotherapy-induced nausea

Memory Aid

• Ginger ale as a symbol for treating nausea

Pharmacology

• Belongs to the drug class of serotonin antagonists
  • Blocks serotonin signaling

Important Side Effect: Serotonin Syndrome

• Rare but life-threatening
• Symptoms:
  • Unstable vitals (tachycardia and hypertension)
  • Muscle rigidity
  • Agitation
  • Restlessness

Recap

• Ondansetron treats nausea and vomiting
• It is a serotonin receptor blocker
• Can cause serotonin syndrome
  • Medical emergency
  • Presents with unstable vitals, muscle rigidity, agitation, and restlessness

Conclusion

• Example: Daughter with stage fright feeling nauseous, treated with ginger ale

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