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Midget Cells: Structure and Function

Apr 25, 2025

Midget Cell

Overview

  • Midget cells, also known as P cells or P ganglion cells, are a type of retinal ganglion cell (RGC).
  • They originate in the ganglion cell layer of the retina and project to the parvocellular layers of the lateral geniculate nucleus (LGN).
  • Axons travel through the optic nerve and optic tract to synapse with parvocellular cells in the LGN.
  • Named for their small dendritic trees and cell bodies.
  • Comprise about 80% of RGCs.

Characteristics

  • Receptive Fields: Circular with antagonistic center and surround, known as spatial opponency.
    • ON-center: Excited by photons in the center.
    • OFF-center: Inhibited by photons in the center.
  • Chromatic Opponency: Often show chromatic opponency with long- and medium-wavelength light.
    • Example: L-ON midget cell excited by long-wavelength light at the center and inhibited by medium-wavelength light at the surround.
    • Not all midget cells are chromatically opponent.
  • Conduction: Slow conduction velocity but responsive to high temporal and low spatial frequencies.

Connections

  • Receive inputs from a small number of rods and cones.
  • Often connected to midget bipolar cells, each linked to one cone.

Additional Information

  • Visual System: Part of the visual system, primarily involved in processing fine visual details due to their connection to the parvocellular pathway which is sensitive to detail and color.
  • Comparison: Midget cells are smaller compared to other RGCs like parasol cells.

Related Cells

  • Parasol Cell: Another type of retinal ganglion cell, larger in size.
  • Bistratified Cell: Another RGC type, involved in different visual processing.

References

  • Eye, human. Encyclopædia Britannica, 2008.
  • Le, Wool; Jd, Crook; Jb, Troy; Os, Packer; Q, Zaidi; Dm, Dacey (2018). "Nonselective Wiring Accounts for Red-Green Opponency in Midget Ganglion Cells of the Primate Retina". The Journal of Neuroscience.
  • Kandel, Eric; Schwartz, James; Jessell, Thomas. Principles of Neural Science, Fourth Edition.