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Sciatic Nerve Overview

Jul 10, 2025

Overview

This lecture explains the anatomy of the sciatic nerve, its role in sciatica, and how its structure and branches relate to clinical symptoms in patients.

Sciatic Nerve Anatomy

  • The sciatic nerve is the largest nerve in the leg, formed from L4, L5, S1, S2, and S3 spinal nerve roots.
  • Irritation often occurs at L4, L5, and S1 levels, commonly due to disc herniation.
  • The nerve exits through the sciatic notch and passes deep to the piriformis muscle.

Causes & Epidemiology of Sciatica

  • Sciatic nerve irritation can be due to various structures in the gluteal (buttock) region, not just piriformis muscle.
  • Deep gluteal pain syndrome is now preferred over "piriformis syndrome" as the cause is often multifactorial.
  • Deep gluteal pain syndrome accounts for only 0.3–6% of sciatica cases.
  • Sciatica typically causes pain, pins and needles, numbness, or burning in the back of the leg, not the front.

Sciatic Nerve Branches and Clinical Relevance

  • Sciatic nerve splits into the tibial nerve and common peroneal (fibular) nerve at the posterior knee.
  • Tibial nerve supplies key muscles for plantar flexion (e.g., gastrocnemius, soleus); weakness here suggests tibial nerve involvement.
  • Common peroneal nerve divides into deep and superficial peroneal nerves (also called fibular nerves).
  • Deep peroneal nerve supplies anterior tibia muscles (dorsiflexors); dysfunction leads to foot drop.
  • Superficial peroneal nerve supplies lateral leg muscles (evertors); weakness means loss of eversion strength.
  • Mnemonic: ADLs—Anterior Deep (deep peroneal), Lateral Superficial (superficial peroneal).

Clinical Signs and Dermatomes

  • Ankle reflex tests S1-S2; a reduction indicates possible sciatica.
  • L4 dermatome: medial tibia; L5: fibular region to first toe; S1: lateral foot.
  • L5 and S1 dermatomes most often affected in sciatica (pins and needles, numbness, especially lateral foot).

Key Terms & Definitions

  • Sciatic nerve — the largest nerve in the leg, formed from L4-S3 spinal nerves.
  • Piriformis syndrome / Deep gluteal pain syndrome — pain caused by structures compressing the sciatic nerve in the gluteal region.
  • Tibial nerve — branch of the sciatic nerve, supplies muscles for foot plantar flexion.
  • Common peroneal (fibular) nerve — sciatic nerve branch splitting into nerves for dorsiflexion and eversion.
  • Dermatome — area of skin supplied by a single spinal nerve root.
  • Foot drop — inability to dorsiflex the foot, a sign of deep peroneal nerve dysfunction.

Action Items / Next Steps

  • Review the anatomy and branching of the sciatic nerve.
  • Practice identifying symptoms corresponding to tibial and peroneal nerve involvement.
  • Learn the dermatomal patterns for L4, L5, and S1.