hey everybody dr. Oh here this fragrant we're gonna cover another class of the protein synthesis inhibited antibiotics so we're going to talk about tetracyclines here so you see that this is the bacterial ribosome it's called a 70s ribosome the S stands for fed bird units no big deal but you see it as a 50s large subunit a 30s small subunit the tetracyclines they are going to bind to this 30s small subunit and they're going to prevent the transfer RNAs that carry the amino acids to add to the chain they're gonna prevent them from actually doing their job which means proteins won't be made so tetracycline is a great example of a protein synthesis inhibitor so this is different than the the aminoglycoside which they both impact the same subunit but they're these are a bacteriostatic which means they inhibit the growth whereas the aminoglycoside antibiotics or bacterial seidel they killed them so these are very broad spectrum tetracycline is probably like when I think of broad-spectrum antibiotics a very very broad spectrum but which means it's been had lots of uses but also a lots of abuses so we'll come back to that in a moment when would you use this so I would say that the the key thing that sets this antibiotic apart is its useful against intracellular bacteria right so all viruses are intracellular pathogens but there are also are some small bacteria that are intracellular pathogens as well chlamydia the Rickettsia switch cause like what Rocky Mountain spotted fever Rocky Mountain spotted fever typhus these types of things so there are there are several pathogens that like to hide inside a cell Manila can do it they like to hide inside of our cells so tetracycline appears to be more effective at getting these intracellular pathogens killed but the broad broad spectrum of tetracycline is is why it can lead to what are called super infections so I've used the word superbugs several times in this series superbugs are multi drug-resistant organisms that are resistant to at least two types of antibiotics super infections are different there are secondary infections but instead of getting a secondary infection because you're immunocompromised you get a secondary infection because of the antibiotics so the antibiotic actually wipes out the protective organisms have which leads to a secondary infection so the two textbook examples of super infections that can occur with other antibiotics but tetracycline is just the first one that comes to my mind would be Candida albicans or yeast infections so you kill off the bacteria the yeast take over or seed if so Clostridium difficile a is a spore-forming bacteria so when you use antibiotics you kill off a lot of its competition so it will sprout up and become a problem alright so we talked about how there bacteriostatic and their broad-spectrum already we talked about how they work they've been around since the 40s when they were first first discovered so what doxycycline would be a good example that's probably the main one that I would think of all right there there are reasons not to use these like any other of antibiotic there are some toxicity concerns and there are some potential side effects the the liver would be something tooth discoloration would be one that comes to mind but and then liver and kidney issues but alright so that is your tetracycline antibiotics like tetracycline doxycycline etc and I hope this helps have a wonderful day be blessed