Lecture Notes on YK-11: A Selective Androgen Receptor Modulator (SARM)

Introduction

• YK-11 is a compound that is considered close to Superdrol in terms of strength gains, size, density, muscularity, and dryness.
• It might be a suitable replacement for Superdrol, which is known for its liver toxicity.
• YK-11 stands out among SARMs due to its unique properties as a steroidal compound.

Characteristics of YK-11

• Selective Androgen Receptor Modulator (SARM)
  • Dual-action drug activating the androgen receptor.
  • Little to no affinity for glucocorticoid, mineralocorticoid, estrogen, or other receptors.
  • Compared to dihydrotestosterone (DHT) in studies.
• Follistatin Secretagogue
  • Increases follistatin levels which inhibit myostatin, promoting muscle growth.
  • Scientific evidence limited to only two studies.

Scientific Evidence

• Described in scientific literature in 2011.
• Evidence is scarce with no human clinical trials or case reports.
• Studies show YK-11 activates androgen receptors, increases bone mineralization, and enhances muscle growth potential.
• Dosages used in animal models are extremely high and not feasible for humans.

Personal Experience

• The compound was used alongside a steroid cycle, making it difficult to isolate its effects.
• Comparable to Superdrol but without the severe liver toxicity.
• Plans to test YK-11 with a solo testosterone base in the future.

Side Effects and Precautions

• Potential Side Effects
  • May cause hair loss when not used with a testosterone base.
  • Neurotoxic effects and increases in oxidative stress noted in animal models.
• Precautions
  • Use antioxidants such as vitamin C, vitamin E, and N-acetyl cysteine while using YK-11.
  • Methylene blue suggested to minimize oxidative stress.

Conclusion

• YK-11 is the only steroidal SARM currently used and under scientific scrutiny.
• Although evidence is limited and mostly from animal studies, it shows promising results in terms of muscle gain with comparatively less toxicity than some other anabolic steroids.
• Continued research and personal experimentation are necessary to confirm its benefits and safety profile.