hello everyone welcome back to daily value I William Wallace and today we'll be discussing new findings about the protective effects of coffee tea and caffeine consumption particularly when it comes to reducing the risk of cardiometabolic diseases like type 2 diabetes coronary heart disease and stroke today's episode will explore how moderate coffee and caffeine cake could play a protective role in preventing cardiovascular disease based on a recent study published in the journal of clinical endocrinology and Metabolism we'll discuss the study's findings potential mechanisms of protection that caffeine might confer the dose at which this protection might be taking place and whether the source of caffeine matters lastly we'll discuss what this could mean for your daily coffee or tea habits as always this podcast is for educational purposes only and should not replace medical advice now let's get into it cardiometabolic diseases such as type 2 diabetes Cor heart disease and stroke are already major contributors to Global mortality but what happens when individuals develop more than one of these conditions at the same time this is called cardiometabolic multimorbidity with only one cardiometabolic disease allc cause mortality risk is twofold higher compared to not having any cardiometabolic disease in cardiometabolic multimorbidity all calls mortality risk goes up four to seven times higher compared to to someone without any cardiometabolic disease or condition interestingly enough there are numerous epidemiological studies that have shown an inverse relationship between coffee tea and caffeine consumption and risk of death from any single cardiometabolic disease now obviously epidemiological inverse Association is not causation but this has been shown enough times to be of note however to this point in time it's not really been known whether or not caffeine intake from coffee or tea had the same inverse relationship with mortality associated with cardiometabolic multimorbidity which again would be the term used for having two or more cardiometabolic diseases coexisting with each other well this is exactly what a recent study published again in the journal of clinical endocrinology and Metabolism sought to determine Based on data from the UK biobank a large longitudinal study involving over 500,000 participants age 37 to 73 years old examined the impact of coffee tea and caffeine intake on the development of cardiometabolic diseases over an 11e period here is what the study found participants who consumed moderate amounts of coffee that is around three cups of coffee had a 48.1% reduced risk of developing cardiometabolic multimorbidity compared to non-consumers similarly when looking at just caffeine content those who consume 200 to 300 milligram of caffeine per day that's roughly equivalent to 2 to three cups of coffee had a 40.7% reduced risk of new onset cardio metabolic comorbidity now interestingly the protective effects of coffee and caffeine were consistent across multiple stages of cardiometabolic disease development including the transition from a healthy state to a single cardiometabolic disease and from one disease to multiple diseases the study suggests a broad protective role of caffeine as it found that regular consumption of coffee tea or caffeine was inversely associated with the risk of developing cardiometabolic multimorbidity in individuals who had no cardiometabolic disease at Baseline even participants who consumed lower amounts of caffeine that's less than 100 milligrams per day showed some degree of protection but the greatest benefit was seen in those who drank at least three cups of coffee or who consumed 200 to 300 milligrams of caffeine daily importantly coffee and caffeine intake appeared to have protective effects in almost every phase of cardiometabolic multimorbidity development this makes a compelling case for the role of moderate coffee and caffeine consumption in maintaining health over time so why does coffee and caffeine seem to protect against cardi metabolic multimorbidity while the exact mechanisms are still not entirely known there are several plausible explanations the first being a pretty obvious one that being the antioxidant and anti-inflammatory effects of coffee and tea specifically coffee and tea are rich in polyphenols and antioxidants such as chlorogenic acid and cakin these compounds have been shown to reduce oxidative stress and inflammation both of which are major drivers of cardiometabolic disease States two would be improved lipid metabolism caffeine consumption has been linked to higher levels of HDL cholesterol and lower levels of LDL cholesterol chlorogenic acid from coffee and kakin and gallic acid from tea but also found a bit and coffee can bind to lower density lipoproteins and protect them from oxidizing the idea has been proposed that different phenolic and antioxidant compounds found in coffee and tea offer more synergistic protection compared to taking in any single antiox compound of the many being described here lastly a recent study showed that caffeine can block the expression of a specific protein in the liver called proprotein converte subtilisin kexin type 9 or pcsk9 now why is this important pcsk9 plays a crucial role in regulating the number of LDL receptors on the surface of liver cells LDL receptors are like tiny catchers that remove LDL from your bloodstream normally pcsk9 reduces the number of these receptors which means more LDL cholesterol ol stays in your blood increasing your risk for heart disease but when caffeine blocks pcsk9 it helps maintain more LDL receptors allowing the liver to clear more cholesterol from the blood in simpler terms caffeine seems to enhance the body's ability to lower low density lipoprotein Levels by making the liver more efficient so what does all of this mean for your coffee and or tea habit well based on the findings we discussed moderate coffee and caffeine consumption could offer protective benefits against developing multiple cardiometabolic diseases if you're free of any cardiometabolic conditions and are looking to maintain long-term heart and metabolic Health here are a few key takeaways aim for moderate coffee intake around three cups per day or consume 200 to 300 milligrams of caffeine per day preferentially from coffee or tea tea drinkers of course you're not left out similar protective effects were observed for people who drank five or more Cups of Tea per day in the study that we just discussed the findings from this study highlight the potential role of coffee and tea and caffeine consumption and reducing the risk of cardiometabolic multimorbidity these results suggest that incorporating moderate amounts of those Beverages and your daily routine could help protect against multiple cardiometabolic diseases over time thank you for joining me today on daily value if you found this episode helpful don't forget to subscribe and share it with others who might benefit until next time take care of your heart and stay healthy