Overview
The video reviews the use of topical finasteride—often combined with minoxidil—for hair loss, comparing it to oral finasteride in terms of safety, effectiveness, and side effects. It provides practical guidance on choosing concentrations and explains how to prepare a homemade topical solution.
Reasons for Choosing Topical Finasteride
- Topical finasteride is favored by those concerned about oral finasteride’s sexual side effects, which affect about 2% of users.
- Topical application can target scalp DHT reduction more directly with lower systemic absorption, potentially reducing side effects.
Comparison of Oral and Topical Finasteride
- Oral finasteride typically reduces serum DHT by 70% but only about 40% of scalp DHT.
- Topical finasteride (depending on concentration) can reduce scalp DHT by 50% or more, and serum DHT by just 25%.
Effective Concentrations and Products
- Commercial topical finasteride products vary: e.g., Hims offers 0.3% solution; Keeps offers 0.25%.
- The optimal concentration for scalp DHT reduction is identified as 0.25% per 1 milliliter, matching Keeps’ product.
DIY Topical Finasteride Preparation
- One method: Grind finasteride tablets (using a coffee grinder) and dissolve in a carrier such as minoxidil solution or a mix of 70% ethanol and 30% propylene glycol.
- The presenter uses a much lower concentration (0.011%) when taking oral finasteride concurrently.
Recommendations / Advice
- Always consult a medical professional before starting topical finasteride or making home solutions.
- Consider starting with a 0.25% concentration for topical application if not using oral finasteride.
Decisions
- Recommend 0.25% topical finasteride concentration as an effective balance of safety and efficacy.
- Suggest homemade preparation only with careful measurement and medical guidance.