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Syncope Evaluation Best Practices

Jul 20, 2025

Overview

This presentation discusses best practices for evaluating syncope, emphasizing the importance of thorough history-taking over extensive diagnostic testing and highlighting guideline-based approaches to risk stratification and patient management.

Importance of Clinical History

  • Taking a detailed patient history is the most valuable tool in evaluating syncope.
  • Structured history tools, such as the Calgary Syncope Score, help differentiate between neurologic and cardiovascular causes.
  • Gathering observations from witnesses can provide critical information about the nature of the syncope episode.
  • Simple, evidence-based questions can guide diagnosis and are effective for teaching healthcare teams.

Appropriate Use of Diagnostic Testing

  • ECG should be performed to rule out suspicious findings but is often sufficient in young patients with vasovagal syncope.
  • Advanced, costly, or invasive tests (e.g., hospitalization, imaging, EEG) yield low diagnostic value unless clinical suspicion exists.
  • Neurologic workups and extensive cardiac imaging should be limited to cases with specific clinical indications.
  • Tilt testing and electrophysiology studies are reserved for unresolved or atypical cases.

Risk Stratification and Hospital Admission

  • Risk assessment should focus primarily on prognosis using emergency department-developed parameters, particularly for cardiovascular comorbidities.
  • Most patients do not require hospital admission and can be managed through observation units or rapid outpatient assessment.
  • Hospital admission should be reserved for patients at high risk of life-threatening arrhythmias or with concerning findings.

Special Considerations in Young Patients

  • Most younger patients with syncope experience vasovagal episodes and require only history and ECG.
  • Detailed history is essential to exclude inherited arrhythmias and conditions such as long QT syndrome, Brugada syndrome, or cardiomyopathies.
  • Warning signs include syncope during exertion, without prodrome, in the supine position, or with a family history of sudden death.

Guidelines and Decision Tools

  • The 2018 ACC guidelines provide clear decision tools, flow diagrams, and recommendations.
  • Clinicians should use these guidelines, especially the executive summary, to inform diagnostic and management strategies.

Conclusions and Recommendations

  • Thoughtful history-taking is foundational for effective syncope evaluation.
  • Limit diagnostic testing to cases where history and clinical suspicion warrant further assessment.
  • Risk stratification should guide diagnostic and admission decisions.
  • Utilize observation units and structured guidelines to optimize patient care and resource use.
  • Maintain vigilance for high-risk features, especially in young patients, through targeted questions.