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Prokaryotic vs Eukaryotic Cells

Sep 19, 2025

Overview

This lecture covers the key differences between prokaryotic and eukaryotic cells, focusing on their structures and defining features important for A-level biology.

Key Differences: Prokaryotic vs. Eukaryotic Cells

  • Prokaryotic cells are much smaller than eukaryotic cells.
  • Prokaryotic cells lack membrane-bound organelles (e.g., mitochondria, nucleus, Golgi apparatus).
  • Both cell types have ribosomes, but prokaryotic ribosomes are smaller (70S vs 80S).
  • Eukaryotic cells have a nucleus with a nuclear envelope, while prokaryotic cells have free, circular DNA.
  • Prokaryotic cell walls contain murine, a glycoprotein; plant cell walls have cellulose, fungi have chitin.
  • Prokaryotic cells may contain plasmids, capsules, and flagella, which are not always present.

Ribosomes

  • Prokaryotic ribosomes (70S) are smaller than eukaryotic ribosomes (80S).
  • Eukaryotic mitochondria and chloroplasts contain some 70S ribosomes for their own protein synthesis.

Genetic Material

  • Eukaryotes have linear chromosomes within the nucleus, associated with histone proteins.
  • Prokaryotes have circular DNA without histones, located in the cytoplasm.

Cell Wall Composition

  • Plant cell walls: cellulose; fungal cell walls: chitin; prokaryotic cell walls: murine.

Additional Prokaryotic Structures

  • Plasmids: small loops of DNA carrying extra genes (e.g., antibiotic resistance).
  • Capsule: thick, slimy protein layer protecting against desiccation and immune response.
  • Flagella (plural; flagellum, singular): rotating tail-like structures for movement.

Key Terms & Definitions

  • Prokaryotic cell — Cell without a nucleus or membrane-bound organelles, e.g., bacteria.
  • Eukaryotic cell — Cell with a nucleus and membrane-bound organelles.
  • Ribosome — Organelle for protein synthesis; 70S in prokaryotes, 80S in eukaryotes.
  • Murine — Glycoprotein making up prokaryotic cell walls.
  • Plasmid — Small, circular DNA in prokaryotes, often carrying resistance genes.
  • Capsule — Protective protein layer outside some prokaryotic cell walls.
  • Flagellum (Flagella) — Whip-like structure used for movement in some bacteria.

Action Items / Next Steps

  • Review comparison tables of cell structure differences.
  • Memorize key definitions and functions of each structure.