you pick up this seemingly random cookbook and as you open it you're not greeted by Italian nor Asian Cuisine instead the pages are titled insulin resistance heart disease liver disease and across all of them there are different diets and recipes to help the patients improve their symptoms and quality of life you go a bit further and come across something called ulcerative clients let me check an inflammatory disease of Unknown Origin affecting mainly the large intestine but impacting digestion as a whole and they're just blank pages which is quite surprising because across the last 30 years we see the number of ulcerative quietus patients double especially in countries that experienced a huge dietary shift due to industrialization so if there's something in the diet that could potentially make ulcerative ctis worse is there a diet that might make it better that might help these patients experiencing these nasty symptoms and usually patients who are malnourished we set out to answer that question so we took mice that already had colitis and Expos them to different diets in one case they had cic restriction eating less than they normally would in the second group they experienced intermittent fasting where they had a small window within their waking period where they actually consumed their food and the third case we had something called a fasting mimicking diet a concoction of different nutrients and Foods aimed at doing the same thing as intermittent fasting having the same effects but without actually doing the fasting itself we saw quite interesting results you see in your small intestines which absorbs the food you have these finger like structures called V in colus patients due to inflammation and additional stress they shrivel up and their capacity to absor nutrients become smaller it decreases significantly with each and every single one of our diets we see those V plump back up and be nice and healthy in the background we also see their inflammatory markers on a genetic level go down down down way down so we can say all of these diets have a positive effect on colitis in mice so we can technically use them interchangeably because we know that sticking to one of these diets can be quite hard one thing should be noted which is restricted diets the ones we tested can have negative impact on these patients because remember they're already Mal Nour so we don't want to throw them off the stairs even further down the hole but there is some potential to actually do this experiment in clinical trials tested in humans and see where it goes but for now you have to excuse me as I write down some recipes for those patients to hopefully help them one day