Effect of Alcohol Intake on Inflammatory Status and Prognosis in Cancer Patients

Authors and Affiliations

• Xiangliang Liu, Wenxin Zhang, Wei Ji, Kaiwen Zheng, Yixin Zhao, Yuwei He, Jiuwei Cui, Wei Li
• First Hospital of Jilin University, Changchun, China
• Zhongnan Hospital, Wuhan University, Wuhan, China

Correspondence

• Jiuwei Cui and Wei Li
• Contact: [email protected], [email protected]

Purpose

• Examine the effect of alcohol on inflammatory status and prognosis in cancer patients.

Methods

• Data from 2929 patients with malignancies from Nov 2011 to Dec 2018.
• Used univariate and multivariate Cox proportional hazards models.
• Constructed a nomogram to predict the impact of alcohol on prognosis.

Key Results

• 18.8% of patients consumed alcohol.
• Alcohol group had significantly shorter overall survival (OS) compared to the non-alcohol group.
• Alcohol significantly associated with poor prognosis in advanced breast cancer and early-stage hepatocellular carcinoma (HCC) without viral hepatitis.
• Daily alcohol intake identified as a risk factor for survival benefits.

Conclusion

• Alcohol intake negatively affects cancer patient outcomes.
• A prognostic scoring system was established to predict survival benefits.

Introduction

• Global burden of alcohol-related diseases including cancer.
• High prevalence of alcohol consumption in China.
• Focus on understanding alcohol's effect on different cancer types.

Methods

Clinical Data Collection

• Inclusion: Diagnosed malignancy, age ≥18, no prior nutritional support treatment.
• Exclusion: Death within 30 days, mixed tumor types, non-participation.

Data Analysis

• SPSS and R software used.
• Statistical tests: Kolmogorov-Smirnov, t-tests, chi-square.
• Cox models to find predictors of survival.

Findings

Patient Characteristics

• Higher alcohol consumption among males and smokers.
• Higher proportion of alcohol history in lung, digestive tract, and esophageal cancers.
• Advanced cancer stages more prevalent in Alcohol group.

Inflammatory Factors

• Higher prealbumin and CRP levels in Alcohol group.
• Alcohol group had higher hand grip strength (HGS) in several cancer types.

Prognosis and Cancer Types

• Shorter OS in Alcohol group for various cancer stages.
• Significant association of alcohol with advanced breast cancer and early-stage HCC prognosis.

Nomogram and Predictive Model

• Established a nomogram with a c-index of 0.751.
• Predictive accuracy confirmed with calibration curves.

Discussion

• Alcohol's role in cancer development and progression via oxidative stress and immune modulation.
• Alcohol metabolites increase inflammatory markers.
• Advanced cancer stages may obscure alcohol's impact.

Limitations and Future Directions

• Real-world study with large sample size but limitations in certain cancer types.
• Need for further investigation into alcohol's effect on cancer prognosis.

Ethics and Funding

• Approved by Ethics Committee of the first affiliated hospital of Jilin University.
• Supported by National Key R&D Program of China.

References

• Key references on alcohol and cancer risk, global burden, and mechanisms.

Journal Information

• Journal of Inflammation Research, open-access publication on inflammation and related areas.