Host: Andrew Huberman, Professor of Neurobiology and Ophthalmology at Stanford School of Medicine.
Guest: Dr. Peter Attia, a medical doctor trained at Stanford University School of Medicine and Johns Hopkins School of Medicine.
Focus: NAD pathway and its potential in improving lifespan and health span.
Key Topics Discussed
NAD Pathway
Received attention as a potential target for improving lifespan.
Discussion on molecules in the pathway: NR, NMN, direct infusions, and oral intake of NAD.
Comparison of methods in terms of cell entry and efficacy for longevity and health span.
Supplementation and Regimens
Huberman and Attia discuss personal choices regarding the intake of NAD, NMN, or NR.
They cover their own supplement regimens related to enhancing health span and/or lifespan.
Framework for Longevity
Discussed approaches to longevity: dos and don'ts, caloric restriction, specific cellular pathways, and comprehensive approaches.
Importance of behavior: moving appropriately, eating right, knowing genetics.
Rapamycin and Its Role
Discussion on rapamycin as an immune modulator with potential geroprotective properties.
Attia's personal experience taking rapamycin and the research supporting its use for lifespan extension.
NAD, NR, and NMN
NR and NMN are precursors to NAD.
Debate on effectiveness: NR can cross cell membranes easily, NMN requires conversion.
NAD's role in energy production via mitochondrial pathways.
Experimental Evidence
Discussion of studies and experiments regarding lifespan extension using NAD-related molecules.
Interventions Testing Program (ITP) as a rigorous tool for testing lifespan interventions.
Supplementation Discussion
Huberman's personal observation on NMN effects (e.g., hair and nail growth, increased energy).
Attia's skepticism about the longevity benefits based on current data.
Biological Age vs. Chronological Age
Discussion on biological aging tests and their reliability.
Huberman’s perspective on using a life chart for tracking life and health metrics.
Closing Remarks
Supplements are generally seen as less critical than lifestyle factors like exercise, sleep, nutrition, and emotional health in determining lifespan and health span.
Final thoughts on the discretion necessary for supplement choices based on individual needs and current scientific evidence.
Conclusion
The podcast emphasizes the importance of scientific scrutiny and personal experience in making informed decisions about health supplements.
Next steps include potential further research and validation of the discussed supplements' effects on health span and lifespan.