Overview of Nasal Vaccines by Dr. Syed

Oct 18, 2024

Lecture on Nasal Vaccines by Dr. Mubeen Syed

Introduction

  • Speaker: Dr. Mubeen Syed from DrBean.com
  • Topic: Nasal Vaccines
  • Current Status:
    • Some vaccines are in trials; results pending.
    • Animal tests show good results with IgG, IgA production, and activation of cytotoxic T cells.

Concerns with Nasal Vaccines

  • Side Effects: Potential local reactions in the nose.
  • Adenovirus: Used in vaccines; could be attacked by existing antibodies in the body before functioning effectively.

Advantages of Nasal Vaccines

  • Stability at room temperature
  • Easier transportation and distribution
  • Potential for higher IgA production compared to intramuscular vaccines

Technology and Companies

  • AstraZeneca (Oxford) and Rokote Labs (Finland)
    • Using adenovirus-based technology
  • Altimmune
    • Also using adenovirus technology; conducting animal studies
  • Avalon GloboCare
    • Utilizing S-layer technology similar to Novavax

Detailed Technology Insights

  • Adenovirus-Based Vaccines

    • Modified adenovirus carries antigens
    • Replication-deficient to prevent in-body multiplication
    • Produces IgG, IgA, and activates cytotoxic T cells

  • S-layer Technology (Avalon GloboCare)

    • Particles mimic virus size with antigens on the surface
    • Avoids adenovirus antibodies issues
    • Potential for fewer side effects

Immune Response and Studies

  • Altimmune Animal Studies:
    • Day 28: High IgG titers, CD8+ T cells, and IgA production
    • Demonstrates robust adaptive immune response

Benefits of Nasal Vaccines

  • Targets mucosal immunity effectively
  • Less dependence on cold storage logistics

Considerations

  • Importance of balancing IgA and IgG responses
  • Maintaining strong surface immunity to prevent virus entry

Conclusion

  • Nasal vaccines offer a promising alternative with logistical and immune response advantages.
  • Ongoing trials and research are crucial to determine efficacy and safety.

Dr. Mubeen Syed expresses gratitude for support and donations through various platforms. Encourages further engagement through likes, subscriptions, and other supporting links.