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Overview of Brain Herniation Syndromes

Apr 24, 2025

Brain Herniation Syndromes

Subfalcine Herniation

  • Description: Brain tissue extends under the falx in the supratentorial cerebrum.
  • Clinical Signs:
    • Small reactive pupils
    • Contralateral leg paralysis

Transtentorial Descending Herniation (Uncal Herniation)

  • Description: Medial temporal lobe pushes downward into the posterior fossa through the incisura.
  • Clinical Signs:
    • Ipsilateral pupil dilation
    • Contralateral hemiparesis
    • Decerebrate posturing

Transtentorial Bilateral Herniation (Central Herniation)

  • Description: Caused by the downward displacement of cerebral hemispheres and basal nuclei.
  • Clinical Signs:
    • Medium-sized fixed pupils
    • Stupor and coma
    • Decorticate posturing
    • Cheyne-Stokes respirations
    • Diabetes insipidus

Transtentorial Ascending Herniation

  • Description: Infratentorial mass effect protrudes upwards compressing the midbrain.
  • Clinical Signs:
    • Nausea and vomiting
    • Progressive stupor

Tonsillar Herniation

  • Description: Cerebellar tonsils protrude below the foramen magnum compressing the medulla and upper cervical spinal cord.
  • Clinical Signs (Cushing Reflex):
    • Hypertension
    • Bradycardia
    • Dyspnea
    • Respiratory arrest

Transcalvarial Herniation

  • Description: Rare, usually due to penetrating injuries to the head and skull leaving a defect/opening for herniation.
  • Clinical Signs:
    • Vary based on whether brain tissue was involved
    • Location of involvement also affects symptoms