Cardiac Cycle Overview

Aug 28, 2025

Overview

This lecture explains the cardiac cycle, detailing the sequence of events during each heartbeat, including the roles of systole, diastole, valve operations, and associated heart sounds.

Cardiac Cycle Phases

  • The cardiac cycle consists of systole (ventricular contraction) and diastole (ventricular relaxation).
  • Systole and diastole are subdivided into smaller phases involving changes in pressure and valve positions.

Electrical Initiation & Atrial Events

  • The SA node initiates the cycle by causing atrial depolarization, seen as the P-wave on ECG.
  • Atrial contraction follows, increasing atrial pressure and pushing blood into the ventricles.
  • Most ventricular filling is passive, not due to atrial contraction.

Ventricular Systole

  • As atrial contraction ends, atrial pressure drops; AV valves close as the pressure gradient reverses.
  • Closing of AV valves creates the first heart sound (S1), marking the start of systole.
  • QRS complex represents ventricular depolarization, leading to ventricular contraction.
  • Isovolumetric contraction occurs when ventricles contract with all valves closed; no blood is ejected.

Ventricular Ejection & End of Systole

  • When ventricular pressure exceeds aortic/pulmonary artery pressure, semilunar valves open and rapid blood ejection occurs.
  • T-wave indicates ventricular repolarization as ejection force decreases.
  • Closing of semilunar valves (as ventricular pressure drops below arterial) creates the second heart sound (S2) and ends systole.

Diastole & Ventricular Filling

  • Isovolumetric relaxation phase begins diastole with both AV and semilunar valves closed; ventricular volume unchanged.
  • Ventricular pressure drops rapidly; atria fill and atrial pressure rises.
  • When ventricular pressure falls below atrial, AV valves open, allowing passive ventricular filling.
  • Atrial contraction completes the filling phase, and the cycle repeats.

Key Terms & Definitions

  • Systole — Ventricular contraction phase of the cardiac cycle.
  • Diastole — Ventricular relaxation phase of the cardiac cycle.
  • Isovolumetric Contraction — Ventricles contract with all valves closed; no volume change.
  • Isovolumetric Relaxation — Ventricles relax with all valves closed; no volume change.
  • AV Valves — Valves between atria and ventricles (tricuspid and mitral).
  • Semilunar Valves — Valves between ventricles and arteries (aortic and pulmonic).
  • S1 — First heart sound, caused by AV valve closure.
  • S2 — Second heart sound, caused by semilunar valve closure.
  • SA Node — Sinoatrial node, initiates the heartbeat.
  • QRS Complex — ECG waveform representing ventricular depolarization.
  • T-wave — ECG waveform representing ventricular repolarization.

Action Items / Next Steps

  • Review ECG waveforms and their corresponding cardiac cycle events.
  • Memorize the sequence of valve movements and associated heart sounds.
  • Understand pressure changes and their influence on blood flow during the cycle.