Bio 30AP –mechanisms of body control
Nervous system- control by
electrical impulses.
(Ch 37 & 38)
Endocrine system- Hormonal
control.
(Ch 40)
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Nervous System
Biology 30AP
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Equilibrium/Homeostasis= balance, the main job of the nervous system! 3 Homeostasis video: http://health.howstuffworks.com/adam-200092.htm
A system (along with the endocrine system) that controls all of the activities of the body.
The nervous system is made of: The brain The spinal cord
The nerves The senses
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Structures & Processes of the Nervous System
Sensory Input:
Monitor both
external and internal
environments.
Integration: Process
the information and
often integrate it with
stored information.
Motor output: If
necessary, signal
effector organs to
make an appropriate
response.The brain is composed of over 100 billion nerve cells!
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Organization of the Nervous System (p367) 2 main divisions:
Central nervous system: Brain &
spinal cord=
coordinate incoming & outgoing info.
Peripheral nervous system: carries
information between the organs/effectors and the CNS.
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Peripheral Nervous System all the portions of the NS outside of the brain and spinal cord.
• Somatic NS
Consists of nerves connected to sensory receptors and skeletal muscles
Permits voluntary action (ex. writing your name)
• Autonomic NS
Consists of the Sympathetic and Parasympathetic
systems (on/off switch) Permits the involuntary functioning of blood
vessels, glands, and
internal organs such as the bladder, stomach and heart
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Cells of the NS
Two types: Glial cells (neuroglial) & neurons.
• The Functions of Glial Cells:
– Hold neurons in place
– Provide neurons
with nutrients
– Insulate neurons
– Remove cellular
debris when neurons die
-defend against infection
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Types of Neurons:
• Sensory Neurons (afferent neurons): relay info about environment from sensory receptors to the CNS.
• Interneurons: link neurons to other neurons (found only in CNS)
• Motor Neurons (efferent neurons): carry impulses from the CNS to the effectors (muscles, organs, glands) produce response
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a. Label the neurons below as a interneuron, motor neuron and a sensory-neuron:
b. Where is each neuron found in the body?
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Anatomy of a Nerve Cell • Neurons: vary in size, and appearance. 3 main jobs (input, integration & output)
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• Cell body: functional portion, when in groups out side of CNS called: ganglion
• Dendrites: short extensions that receive signals from other neurons or environment
• Axon: long extension that transmits impulses away to other neurons or effectors.
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Myelinated Neurons
• Myelin sheath: peripheral neurons have white insulation around the axon called which is formed by Schwann cells.
– Myelin sheathing acts as an insulator preventing the loss of charged ions from the axon, and allows conduction of faster nerve impulses.
• Areas between myelin sheath: Nodes of Ranvier
• Neurilemma: membrane surrounding axon, that promotes
regeneration
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Decreased impulses
to muscles
If MS causes nerve signal loss, how would this effect the muscles, the brain, and other organs?
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1.
2.
3.
5.
6.
7.
STOP & THINK!:
what does 1-7 represent?
1. Dendrites
2. Cell body (nucleus)
3. Axon
4.
4. Schwann Cell
5. Myelin Sheath
6. Node of Ranvier
7. Neurilemma
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Question # 1
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Reflex Arc
Reflex arc: 5 steps
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REFLEX ARC: automatic response controlled primarily by spinal cord. stimulus → receptor → sensory neuron → interneuron → motor neuron → effector organ → response
Reflex videos:
http://bcs.whfreeman.com/WebPub/Biology/hillis1e/Animated%20Tutorials/at3404/at_3404_info_proc_spinal_
cord.html
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2. http://health.howstuffworks.com/adam-200012.htm
.htt:www.sumanasinc.comwebcontentanisamlesnonmaorsbioloreflexarcs.html
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Question # 2
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Nerve Impulses (pg372)
Nerves have two states:
1. Resting potential
• “polarized”
• Resting nerve
• Charge inside is -70mV
2. Action potential
• “depolarized” nerve
• Charge inside jumps to +40mV
21 Restin membrane: htts://www.outube.com/watch?v=b2ctEsGEe0&t=19s
Resting Membrane Potential • The membranes contain
sodium-potassium pumps
that pump out 3 Na+ and 2
K+ in.
• HOW -70mV?
– Uses ATP (active transport) to
pump 3 sodium ions out and 2
potassium ions in. this unequal
distribution of ions leads to a
polarized membrane.
– Presence of negatively charged
plasma proteins and ions
– K+leak channels allow K+to leave
the inside of the axon.
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Nerve Impulse - The Action Potential
Steps:
1. Depolarization: Nerve becomes more permeable to highly concentrated Na+ than K+. This rapid influx of Na+ causes -70 to jump to +40mV.
2. Repolarization: Na+ channels close, K+ gates open, and K+ diffuses out of cell restoring original polarization.
3. Refractory Period: recovery time (1-10ms) required before a neuron can return to resting potential. pumping time required to produce another action potential
Hyperpolarization: K+ gates close slowly , so more K+ ions move out than normal = more negative charge inside.
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• Impulse video: https://www.youtube.com/watch?v=bfokof2YMVU&t=148s
Nerve Impulse - The Action Potential Threshold potential will trigger an
action potential or nerve impulse
-The action potential is an all-or-none
response, moves like a wave from cell
body down the axon to next neuron.
-Positively charged ions that rush into the
neuron are attracted to adjacent negative
ions.
-Hyperpolarization in previous area (in
refractory period) stops impulse from
traveling backwards (re-pump Na+ back
out before another impulse can be sent)
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Saltatory Conduction in Myelinated
Axons
Myelin sheathing has bare patches called nodes
of Ranvier
•Action potentials seem to jump from node to
node (saltatory conduction)
•Faster conduction than unmyelinated action potential
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Myelination:
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Nerve impulse: https://www.youtube.com/watch?v=fHRC8SlLcH0&t=3s1. Identify and explain the three factors that contribute to the resting membrane potential. 2. Explain the difference between depolarization and the repolarization of a neuron?
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Threshold: All-or-none Threshold level: minimum level of stimulus
required to produce a response (> 2mV)
All-or-none response: nerves or muscles
respond completely or not at all.
• Charge greater than minimum required
will not produce a increased response
Message priority determined by:
1. More frequency of impulses (spinal gate
theory)
2. Some neurons have higher threshold
levels, they only fire with an increased
stimulus
Therefore: The greater the number of
impulses reaching the brain the greater the
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intensity of the response.
The Synapse – The space between!
• A synaptic cleft divides
at least 2 (usually more)
neurons by ~20nm.
• Presynaptic Neurons:
carry impulses to the
synapse
• Postsynaptic Neurons:
carry impulses away
from synapse
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How does a signal move
from one neuron to another?
• The action potential will not move
across the synapse
• More synapses= slower transmission. (reflex arc has little synapses)
Neuro-transmitters (chemicals)
brave the gap:
•Released by the end plate of
presynaptic neuron to the
receptor sites of
postsynaptic neuron.
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•Move by diffusion
Mechanism of Neurotransmission
1. Action potential reaches end plate
2. Ca2+ gates open influx of + ions
3. Build-up of Ca2+ causes release of
acetylcholine
4. Acetylcholine released
5. Acetylcholine binds with Na+ channels
opening them (postsynaptic receptor sites)
6. Na+ ions rush in causing depolariazation.
7. Action potential continues through dendrite
of post synaptic neuron.
8. Presynaptic endplate membrane releases
cholinsterase (enzyme) which destroys
acetylcholine
9. Na+ gates close, recovery phase begins
Chemical synapse videos:
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http://bcs.whfreeman.com/WebPub/Biology/hillis1e/Animated%2520Tutorials/at3403
/at_3403_synaptic_trans.html
Neurotransmitter Jobs
• Excitatory: triggers receptor proteins in post synaptic cleft to allow positive ions in (ex. sodium) →
Depolarization! & lowered threshold level!
• Inhibitory: triggers potassium channels to open→ hyperpolarization! (increased threshold level)
Common Neurotransmitters: Dopamine
Function:
Sensation of pleasure + body mov’t
Serotonin
Regulates temp. + perception + mood control
Endorphins
Natural painkiller + emotions
Norepinepherine
Works with epinephrine (fight-flight response)
GABA
Inhibitory (natural tranquilizer)
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What would happen if the neurotransmitter on the post synaptic neuron was not broken by cholinesterase?
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Synaptic wonders Summation:
Quit messing with my synapses!
-effect produced by the accumulation of transmitter chemical from two or more neurons.
-can be inhibitory or excitatory
threshold
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Neurotransmitter disorders
Parkinson's Disease:
-inadequate dopamine (inhibitory)
causes involuntary muscle contraction -Michael j fox
Alzheimer’s Disease:
-inadequate acetylcholine (excitatory) deterioration of memory & mental
capacity.
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How does the drug cocaine affect synaptic transmission?
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Question
# 3
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Question # 4
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Question # 5
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Question # 6
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Question # 7
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Question # 8
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Question # 9
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* The Central Nervous System controls all of the body’s activities.
* The Central Nervous System is made of two main organs.
1. The brain
2. The spinal cord
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Protecting the CNS
Control center consisting of brain & spinal cord • Skull/vertebrae: bone covering
• Brain surrounded by protective
membranes: Meninges
– Outer layer: dura mater
– Middle layer: arachnoid
– Inner layer: pia mater
• Cerebrospinal fluid: transport
medium & shock absorber that
circulates between inner &
middle meninges and the central
canal of the spinal cord.
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• Carries sensory nerve messages from receptors to the brain and relays messages from the brain to effectors (muscles, organs & glands).
• Foramen magnum: opening in skull for spinal cord • Spinal cord travels within the vertebral backbone
Gray vs white:
• Gray: unmyelinated neurons/axons
• White: myelinated neurons that connect spinal cord to brain Dorsal vs ventral:
• Dorsal nerve: brings sensory info in
• Ventral nerve: carries motor info out to effectors (muscles/glands)
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Dorsal root ganglion
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3 regions:
Forebrain
(reason, intellect, memory, language, personality)
Midbrain
(relay center for eye & ear)
Hindbrain
(balance, muscle control, autonomic control)
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Gray matter
White
matter
Ventricles
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Forebrain
Contains:
• Cerebrum: largest portion of brain, surface is the cerebral cortex (gray matter).
– coordinating center for:
• Motor actions, speech, reasoning, memory, personality
– 2 distinct hemi-spheres (left: verbal skills, right: visual/spatial awareness) linked by the corpus callosum (communication bridge)
– Each hemi-sphere has 4 lobes:
• Frontal, temporal, parietal, and occipital
• Thalamus: interprets sensory information (relay station)
• Hypothalamus & Pituitary: unites nervous and endocrine systems (autonomic functions)
• Olfactory bulbs: detect smell
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Cerebrum lobes:
Frontal:
-voluntary muscles
(walking, speech)
-personality
-memory
Temporal:
-interpret sensory info
(hearing, smell)
Parietal:
-touch, pain, taste
(temperature)
-emotions
-Interpreting speech
Occipital:
- vision
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Midbrain
• 4 spheres of gray matter
• Relay center for eye & ear reflexes
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Hindbrain
Contains:
• Cerebellum: controls limb mov’t, balance, muscle tone
• Pons: (bridge) relay station between two regions of cerebellum and the medulla
• Medulla Oblongata: joins spinal cord to cerebellum, site of autonomic nerve control (breathing mov’ts, diameter of blood vessels…)
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Interpreting Speech
• In Cerebrum:
• Broca’s Area: coordinates speech
muscles & translates thoughts into
speech (Frontal lobe)
• Wernicke’s Area: language
comprehension & storage. (left
Temporal lobe)
Silk & Milk
Out loud get your partner to spell S-I-L-K. Repeat. Repeat.
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Now get your partner to say "silk" three times fast.
Now ask them what do cows drink...
Brain mapping
• Different areas have
specific functions
• Other areas can
substitute for
Damaged areas.
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Lips
Jaw
Tongue
Frontal lobe Parietal lobe
Toes
Pharynx
Genitalia
Primary
motor cortex
Abdominal organs
Primary
somatosensory cortex
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Brain imaging technology
PET (positron emission tomography)- radioactive glucose is consumed in certain areas of the brain.
MRI (magnetic resonance imaging)- giant magnet detects changes in H+ that emit radio signals.
MRI game:
https://educationalgames.nobelprize.org/educational/me dicine/mri/game/index.html
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Hearing words
Speaking words
Seeing
words
Generating words
Max Min
LABEL The Brain Cerebrum
Corpus Callosum
Hypothalamus
Pituitary Gland
Pons
Cerebellum
Medulla Oblongata
Question # 10
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Question # 11
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Question # 12
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Question # 13
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Question # 14
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Peripheral Nervous System
PNS 2 parts:
Both contain sensory
and effector nerves
1. Autonomic system:
nerves designed to
maintain internal
homeostasis (not under
conscious control)
2. Somatic system:
designed to adjust to
external stimuli by
controlling skeletal muscle
(under conscious control),
exception - reflexes
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Composed of:
A. 12 paired cranial nerves
– Control vision, hearing, balance, taste, smell, facial, tongue, neck & head mov’t B. 31 paired spinal nerves
– Control skeletal muscles
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Sensory Somatic System Divisions
A. Cranial nerves
B. Spinal nerves
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Involuntary internal homeostatic control.
Ex. Controls smooth muscle, internal
organs, glands
controls
2 types of ANS nerves:
1st group: preganglionic (CNS→ ganglion)
2nd group: postganglionic (ganglion → target organ/gland/muscle)
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Comparison of Somatic and Autonomic Systems76
Autonomic Nervous System halves
Sympathetic (on) • Prepares body for stress (fight or flight)
• Short preganglionic nerve
• Preganglionic nerves release acetylcholine. Postganglionic release norepinepherine.
• Come from the thoracic (ribs) & lumbar (small of back) vertebrae
Parasympathetic (off) • Restores balance (rest & digest)
• Long preganglionic nerve
• Preganglionic & postganglionic release acetylcholine.
• Come from the brain, cervical (neck) or the caudal (tail bone) area.
• Master “off” nerve: Vagus Nerve controls:
– Heart, Bronchi, Liver, Pancreas, Digestive tract
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Chapter 13 Nervous System 79
Fill in the missing actions of the parasympathetic and Sympathetic ANS:
(letters a-f)
a.
b.
c.
d.
e.
f.
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