Alright, in this video, I'm going to talk
about systemic lupus erythematosus, or SLE. So if you're following along with cards, I'm
on card number 12. SLE is a chronic inflammatory disorder of
the connective tissue and it causes widespread inflammation as well as tissue damage. Now, keep in mind as I go through this information,
I'm talking about systemic lupus and not discoid lupus, which primarily just affects the skin. So in terms of the pathophysiology behind
this disorder, systemic lupus is an autoimmune disorder which results in the production of
antinuclear antibodies, or ANA. And this results in inflammation and damage
to many organs in the body, including the skin, the lungs, the kidneys, and the heart. And just like other autoimmune disorders,
lupus is characterized by periods of exacerbations as well as periods of remission. In terms of the risk factors, women are much
more likely to get lupus. Onset of the disease usually occurs between
the ages of 20 and 40. And race also plays a role, so African Americans,
Asians, and Native Americans are at higher risk for getting lupus. Signs and symptoms of systemic lupus include
fatigue, joint pain, fever, a butterfly rash across the face. So that's one of the hallmark symptoms of
this disorder, as well as Raynaud's phenomenon. So with Raynaud's, you have vasospasming,
so decreased blood flow to the extremities, to the fingers. So those fingers become pale, numb, and cold. So if you Google Raynaud's, you'll see lots
of pictures of pale fingers and you can imagine that they're probably numb and cold, too. Other symptoms include anemia, pericarditis,
which is inflammation of the membrane that surrounds the heart, as well as lymphadenopathy,
so enlarged lymph nodes. In terms of the labs and how we would diagnose
this condition, patients who have lupus will usually have a positive ANA titer and they
will also have decreased serum complement, so decreased C3 and C4. In addition, they'll have decreased red blood
cells, white blood cells, and platelet counts. And then, if their kidneys become involved
at some point, then we would see an increase in BUN and creatinine as well. In terms of treatment, NSAIDs can be used
but we also usually provide immunosuppressants to patients with lupus because it is an autoimmune
disorder and we're trying to suppress that immune system. So medications that fall within this class
include prednisone as well as methotrexate. Hydroxychloroquine is also an effective medication
for lupus. So hydroxychloroquine is actually a medication
used for malaria but it is also used for autoimmune disorders such as lupus. And then, the provider may also prescribe
a topical steroid cream for the rash on the face, for that butterfly rash. In terms of nursing care, in addition to providing
these medications, you're going to really monitor for complications, including renal
failure. And then you're going to provide some important
teaching to your patient. So some of those key teaching points include
avoiding UV and sun exposure to prevent skin damage. Also, the patient needs to really prevent
infection, so they should avoid sick people and really protect themselves from getting
infection. And then they need to take frequent rest periods
as well because of that side effect of fatigue associated with systemic lupus. Okay, so that's it for lupus. When I come back on my next video, we will
talk about scleroderma. Thank you so much for watching!