Ondansetron (Zofran) Lecture Notes

Introduction

• Ondansetron (brand name: Zofran)
• Used to treat nausea and vomiting
• Important for NCLEX: Know the generic name

Memory Anchor

• Visualize a dancer for "ondansetron"
• Imagine a daughter with stage fright and nausea
• Ginger ale for treating upset stomach
• Ginger ale used as a mnemonic for its function in treating nausea and vomiting

Uses

• Treats nausea and vomiting, especially:
  • Post-operative nausea
  • Chemotherapy-induced nausea

Mechanism of Action

• Drug class: Serotonin receptor antagonists
• Blocks serotonin signaling
• Serotonin is the "feel-good" hormone symbolized by a happy face

Side Effects

• Serotonin Syndrome (rare but life-threatening)
  • Caused by abnormalities in serotonin signaling
  • Symptoms include:
    • Unstable vitals (tachycardia, hypertension)
    • Muscle rigidity
    • Agitation and restlessness
  • Requires immediate medical attention

Review Summary

• Ondansetron: Treats nausea and vomiting
• Blocks serotonin receptors: Can cause serotonin syndrome
• Remember unstable vitals, muscle rigidity, agitation, and restlessness as symptoms of serotonin syndrome

Conclusion

• Ginger ale mnemonic seemed effective
• Daughter ready to perform
• For more resources, check out additional materials and subscribe to the channel!