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Hematologic System Overview

May 13, 2024

Hematologic System Overview

Introduction

  • The hematologic system is complex and vital for the integration of all body systems, ensuring functioning and homeostasis.
  • It includes processes like clot formation, dissolution, oxygenation, and transport mechanisms.

Functions of the Hematologic System

  • Clot Formation and Dissolution: Involves the formation of a platelet plug and the administration of antiplatelet and anticoagulant drugs which are high-risk medications.
  • Oxygenation: Essential for normal cellular metabolism and to prevent cell death.
  • Transport: Blood's transport mechanism unites all body systems, maintaining wholeness and connectivity.

Components of Whole Blood

  1. Plasma:
    • Accounts for 55% of whole blood's volume.
    • Comprises 92% water, 6% plasma proteins, and 2% solutes.
  2. Formed Elements: Solid components of blood including platelets, leukocytes (white blood cells), and erythrocytes (red blood cells).
    • Platelets (Thrombocytes) are crucial for clotting.
    • Leukocytes (White Blood Cells) vary in types but are essential for immune defense.
    • Erythrocytes (Red Blood Cells) carry oxygen throughout the body.

Albumin

  • Plays a key role in oncotic pressure and the transport of substances within the intravascular space.
  • Normal levels range from 3.5 to 5 g/dL.
  • Hypoalbuminemia can cause edema and affect perfusion and blood pressure.

Ions and Solutes

  • Include positively charged ions like potassium, sodium, and calcium, critical for cardiac conduction and metabolic processes.

Nutrients and Waste Products

  • The blood carries essential nutrients and is crucial for the elimination of waste products, affecting organ balance and homeostasis.

Regulatory Substances

  • Hormones play significant roles in bodily functions, with abnormalities leading to disease.

Blood Cells Details

  • Platelet Counts: Normal ranges from 150,000 to 350,000.
  • Leukocytes: Important for identifying infection; normal range is 5,000 to 10,000.
  • Erythrocytes: Carry hemoglobin; each cell contains about 300 hemoglobin molecules, essential for oxygen transport.

Spleen and Liver Functions in Hematology

  • Spleen: Filters blood and stores old blood components.
  • Liver: Manufactures plasma proteins like albumin and prothrombin, and bile for fat digestion.