Amphotericin B Mnemonic Lecture Notes

Introduction

• Amphotericin B: Antifungal for severe systemic fungal infections.
• Reserved for most severe cases due to many adverse effects.
• Mnemonic setting: Man's kitchen with frog legs (amphibians) to remember Amphotericin B (amphibian).

Clinical Use

• Treats severe systemic fungal infections.
• Used as a last resort due to severe side effects.

Adverse Effects

Nephrotoxicity

• Symbol: Kidney beans knocked to the floor.
• Effect: Kidney toxicity (nephrotoxicity).
• Monitoring: BUN, creatinine, urine output levels.

Hypokalemia

• Symbol: Empty banana peel (low potassium).
• Effect: Low potassium levels (hypokalemia).
• Intervention: Potassium supplementation may be needed.

Hypomagnesemia

• Symbol: Falling magnets (magnesium).
• Effect: Low magnesium levels (hypomagnesemia).
• Intervention: Magnesium supplementation may be needed.

Infusion-Related Reactions

• Symbol: Date's bad reaction (fever, chills, nausea, hypotension).
• Reaction: Acute reaction to infusion with symptoms like fever, chills, nausea, hypotension.
• Management: Pre-infusion medications (antipyretics, anti-emetics) can be used.
• Important: Reaction is expected; do not stop the infusion or notify the provider.

Summary

• Amphotericin B: Last-resort antifungal for severe infections.
• Side Effects: Nephrotoxicity (monitor kidney function), hypokalemia (potassium supplementation), hypomagnesemia (magnesium supplementation), and infusion-related reactions (fever, chills, nausea, hypotension).

Conclusion

• Recommend safer recipes for dinner dates.
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