Rifampin - Key Points

Overview

• Drug: Rifampin
• Use: Treatment of tuberculosis (anti-tubercular agent)
  • Action: Interferes with RNA synthesis of tubercular bacterial cells
• Mnemonic: Rifle (sounds like Rifampin)

Administration

• Combination Therapy: Used with at least one other anti-tubercular agent

Side Effects

Red-Orange Bodily Fluids

• Symbol: Orange soda (boy filling water rifle with orange soda)
• Details: Turns urine, tears, saliva, and sweat reddish-orange
• Advice: Harmless but may discolor contact lenses; suggest using glasses

Hepatotoxicity

• Symbol: Liver lever (lever used to shoot water rifle)
• Signs and Symptoms: Jaundice, weakness and fatigue, elevated ALT and AST
• Advice: Avoid other hepatotoxic substances (e.g., acetaminophen, alcohol)

Decreased Effectiveness of Oral Contraceptives

• Symbol: Ducklings (many ducklings swimming away)
• Advice: Use additional contraception to avoid unintended pregnancies

Summary

• Rifampin: Anti-tubercular medication
  • Side Effects: Reddish-orange bodily fluids; monitor for hepatotoxicity
  • Oral Contraceptives: Reduces effectiveness; use additional contraception

Important Points to Remember:

• Use mnemonic aids (water rifle, orange soda, liver lever, ducklings) to recall key facts
• Teach patients proper precautions to manage side effects and reduce risks